Topical tac
Topical tac is a topical anesthetic solution[1] introduced by Pryor et al. in 1980. It is a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride (hence the "TAC" nomenclature). It has been used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly. Use in the pediatric patient cohort has been documented, including when children have been injured in the eye, ear, or other sensitive locations.[2][3][4]
Due to drug diversion concerns surrounding the use of cocaine in medicine, along with concern regarding toxicity and expense, the cocaine was replaced with lidocaine and a new anesthetic was created -
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References
External links
- Tipton GA, DeWitt GW, Eisenstein SJ (November 1989). "Topical TAC (tetracaine, adrenaline, cocaine) solution for local anesthesia in children: prescribing inconsistency and acute toxicity". Southern Medical Journal. 82 (11): 1344–6. PMID 2814620.
- US patent 5942543, Ernst, Amy A., "Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use", issued August 24, 1999
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