Topilutamide
Drug class | Nonsteroidal antiandrogen |
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ATC code |
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Topilutamide, known more commonly as fluridil and sold under the brand name Eucapil, is an antiandrogen medication which is used in the treatment of pattern hair loss in men and women.[6][1][2][3][4][5] It is used as a topical medication and is applied to the scalp.[1][2][3][4][5] Topilutamide belongs to a class of molecules known as perfluoroacylamido-arylpropanamides.[6]
Topilutamide is a nonsteroidal antiandrogen (NSAA), or an antagonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[1][2][3][4][5]
Topilutamide was introduced for medical use in 2003.[7] It is marketed only in the Czech Republic and Slovakia.[8] The patent for Topilutamide expired in 2020.[6]
Medical uses
Topilutamide is used as a
Available forms
Under the brand name Eucapil, topilutamide is available as a 2% topical
Pharmacology
Pharmacodynamics
Topilutamide is an antagonist of the AR, the biological target of androgens like testosterone and DHT.[1][2][3][4][5] Fluridil binds to the androgen receptor with approximately a 9-15-fold higher affinity than more primitive NSAAs such as bicalutamide and hydroxyflutamide, but more research is required to validate these findings.[6]
Compound | 3 μM | 10 μM |
---|---|---|
BP-766 (Topilutamide) | 41 ± 5 | 95.9 ± 6 |
BP-521 | 62 ± 7 | 100 |
BP-34 | 3 ± 4 | 2 ± 2 |
Bicalutamide | 3 ± 3 | 11 ± 3 |
Hydroxyflutamide | 2 ± 6 | 6 ± 7 |
Pharmacokinetics
Topilutamide is a
Chemistry
Topilutamide is a nonsteroidal compound and is closely related to other NSAAs such as flutamide and bicalutamide.[7]
History
Topilutamide was introduced for medical use in 2003.[7]
Society and culture
Generic names
Topilutamide is the
Brand names
Topilutamide is marketed by Interpharma Praha under the brand name Eucapil.[7][3]
Availability
Topilutamide is available only in Europe in the Czech Republic and Slovakia.[8]
See also
References
- ^ S2CID 36439600.
- ^ ISBN 1-4160-3104-9.
- ^ a b c d e f g h Scripta Medica. 2006. pp. 45, 53–54.
Fluridil was developed as a topical antiandrogen, suitable for the treatment of hyperandrogenic skin syndromes. The cosmetic product Eucapil® containing 2% fluridil in isopropanol was tested in women with AGA in a 9-month open study. [...] In a clinical study conducted at our facility, fluridil in solution (Eucapil®, Interpharma Praha, Czech Republic) has been shown to be effective and safe in the treatment of men with androgenetic alopecia (30, 31).
- ^ ISBN 978-1-139-48339-1.
- ^ ISBN 978-1-4398-0807-8.
- ^ S2CID 98640343.
- ^ PMID 16821162.
- ^ a b c "Androgenetic Alopecia,Hair loss,Eucapil". www.eucapil.com.
- ^ Chambers M. "ChemIDplus - 260980-89-0 - YCNCRLKXSLARFT-UHFFFAOYSA-N - Topilutamide [INN] - Similar structures search, synonyms, formulas, resource links, and other chemical information". chem.nlm.nih.gov.
- ^ "Microsoft Word - final_PL91.doc" (PDF). Retrieved 2018-10-04.
- ISBN 978-1-4578-1723-6.