Trans-activation response element
(Redirected from
Trans-activation response element (TAR)
)| Trans-activation response element (TAR) | |
|---|---|
| SO | SO:0000233 SO:0001244 |
| PDB structures | PDBe |
The
promoter and for virus replication. The TAR hairpin is a dynamic structure[1] that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter.[2]
Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.[3] These miRNAs are thought to prevent infected cells from undergoing
Human polyomavirus 2 (
JC virus) contains a TAR-homologous sequence in its late promoter[6] that is responsive to HIV-1 derived Tat.[7][8]
References
External links
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