Transcellular transport
Transcellular transport involves the transportation of
Transcellular transport can occur in three different ways active transport, passive transport, and transcytosis.Active Transport
Main article: Active transport
Active transport is the process of moving
Passive Transport
Main article: Passive transport
Passive transport is the process of moving molecules from an area of high concentration to an area of low concentration without expelling any energy. There are two types of passive transport, passive diffusion and facilitated diffusion. Passive diffusion is the unassisted movement of molecules from high concentration to low concentration across a permeable membrane.[3] One example of passive diffusion is the gas exchange that occurs between the oxygen in the blood and the carbon dioxide present in the lungs.[4] Facilitated diffusion is the movement of polar molecules down the concentration gradient with the assistance of membrane proteins. Since the molecules associated with facilitated diffusion are polar, they are repelled by the hydrophobic sections of permeable membrane, therefore they need to be assisted by the membrane proteins. Both types of passive transport will continue until the system reaches equilibrium.[5] One example of facilitated diffusion is the movement glucose from small intestine epithelial cells into the extracellular matrix of the blood capillaries.[6]
Transcytosis
Main article: Transcytosis
Transcytosis is the movement of large molecules across the interior of a cell. This process occurs by engulfing the molecule as it moves across the interior of the cell and then releasing the molecule on the other side. There are two types of transcytosis are receptor-mediated transcytosis (RMT) and adsorptive-mediated transcytosis (AMT). An example where both types of transcytosis occur is the movement of macromolecules across the blood-brain barrier (BBB) into the central nervous system (CNS).[7]
Paracellular Transport
In contrast, paracellular transport is the transfer of substances across an epithelium by passing through an intercellular space between the cells.
- 1. It differs from transcellular transport, where the substances travel through the cell passing through both the apical membrane and basolateral membrane
- 2. Renal physiology. Transcellular transport is more likely to involve energy expenditure than paracellular transport.
- 3. Capillaries of the blood–brain barrierhave only transcellular transport, in contrast with normal capillaries, which have both transcellular and paracellular transport.
References
- ISBN 978-1451110395.
- ^ "Primary Active Transport - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2021-11-29.
- ^ "5.2A: The Role of Passive Transport". Biology LibreTexts. 2018-07-10. Retrieved 2021-11-29.
- S2CID 14808756.
- ^ "5.2 Passive Transport - Biology 2e | OpenStax". openstax.org. Retrieved 2021-11-29.
- PMID 26784222.
- ^ "Transcytosis - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2021-11-29.