Transcription factor II D

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Transcription factor II D (TFIID) is one of several

transcription, the transcription Factor II D (TFIID) complex binds to the core promoter DNA of the gene through specific recognition of promoter sequence motifs, including the TATA box, Initiator, Downstream Promoter, Motif Ten, or Downstream Regulatory elements.[1]

Functions

  • Coordinates the activities of more than 70 polypeptides required for initiation of transcription by RNA polymerase II
  • Binds to the core promoter to position the polymerase properly
  • Serves as the scaffold for assembly of the remainder of the transcription complex
  • Acts as a channel for regulatory signals

Structure

TFIID is itself composed of TBP and several

promoters that contain a TATA box.[2] TAFs, however, add promoter selectivity, especially if there is no TATA box sequence for TBP to bind to.[1] TAFs are included in two distinct complexes, TFIID[3] and B-TFIID.[4] The TFIID complex is composed of TBP and more than eight TAFs. But, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170 (BTAF1) in a 1:1 ratio.[5] TFIID and B-TFIID are not equivalent, since transcription reactions utilizing TFIID are responsive to gene specific transcription factors such as SP1, while reactions reconstituted with B-TFIID are not.[5]

Subunits in the TFIID complex include:[2]

See also

References

  1. ^
    PMID 27007846
    .
  2. ^
    PMID 11092823
    .
  3. S2CID 5000858
    .
  4. ^ "NCBI Entrez GeneID: 9044 BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170 kDa (Mot1 homolog, S. cerevisiae)".
  5. ^
    PMID 1387711
    .
  6. PMID 25661246
    .

External links


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