Tremorine

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Tremorine
Clinical data
ATC code
  • none
Identifiers
  • 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine
JSmol)
  • C2CCCN2CC#CCN1CCCC1
  • InChI=1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2
  • Key:JSUAJTLKVREZHV-UHFFFAOYSA-N

Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs.[1][2][3][4][5] Beta blockers are also effective in counteracting the effects of tremorine.[6]

History

Tremorine was first reported by Everett et al. in 1956-57.[7][8][9][10]

References

  1. S2CID 4173699
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  2. S2CID 37472968
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  3. doi:10.1016/0031-6989(71)90005-1
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  4. S2CID 7607662
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  5. S2CID 28371865
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  6. PMID 2883120
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  7. ^ Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousand compounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."
  8. ^ Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.
  9. ^ Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.
  10. ^ Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.

See also

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