Triamcinolone acetonide

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Triamcinolone acetonide
Clinical data
Trade namesKenalog, Nasacort, Xipere, others
AHFS/Drugs.comMonograph
MedlinePlusa601124
License data
Pregnancy
category
  • AU: B3/ A
Routes of
administration		Topical, joint injection, nasal
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver
ExcretionUrine (75%) and feces (25%)
Identifiers
  • (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
JSmol)
Melting point290 to 294 °C (554 to 561 °F)
  • C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@@]53C)F)O
  • InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1 checkY
  • Key:YNDXUCZADRHECN-JNQJZLCISA-N checkY
 ☒NcheckY (what is this?)  (verify)

Triamcinolone acetonide, sold under the brand name Kenalog among others, is a

mouth sores, and by injection into joints to treat various joint conditions. It is also injected into lesions to treat inflammation in some parts of the body, particularly the skin. In nasal spray form, it is used to treat allergic rhinitis. It is used for the treatment of macular edema associated with uveitis.[11] It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.[14]

Most forms of triamcinolone acetonide are

generic medication.[15]

Medical uses

Triamcinolone acetonide as an intra-articular injectable has been used to treat a variety of musculoskeletal conditions. When applied to the skin as a topical ointment, it is used to mitigate blistering from

aphthous ulcers
.

As an intravitreal injection, triamcinolone acetonide has been used to treat various eye diseases and has been found useful in reducing

VEGF drugs in eyes with artificial lenses over a two-year period. A systematic review did not find any evidence of any benefit in preventing vision loss in eyes treated with triamcinolone acetonide over placebo, for patients with age-related macular degeneration.[18]

Triamcinolone acetonide is also administered via intralesional injection in the treatment of hypertrophic and keloid scars.[19][20]

Contraindications

Evidence suggests that usage of triamcinolone acetonide or other steroids to treat macular edema increases the risk of increasing intraocular pressure in patients.[21]

Triamcinolone acetonide should not be used by those with

herpes simplex infections
without consulting a doctor first.

Pharmacology

Pharmacodynamics

Further information: Glucocorticoid § Mechanism of action

Triamcinolone acetonide is a

menstrual irregularities.[24][25][26]

Chemistry

See also: List of corticosteroids

Triamcinolone acetonide, also known as 9α-fluoro-16α-hydroxyprednisolone 16α,17α-acetonide or as 9α-fluoro-11β,16α-17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, is a

cyclic ketal pregnane corticosteroid.[27] It is the C16α,17α acetonide of triamcinolone.[27]

Veterinary use

Triamcinolone acetonide is also used in

pruritus in dogs.[28]

A series of injections with triamcinolone acetonide or another corticosteroid may reduce keloid size and irritation. It is used as a preinductor and/or inductor of birth in cows. It was also used in the horse racing industry, but it is now a banned substance if found in a horse's system on race day.[29]

References

  1. FDA
    . Retrieved 22 October 2023.
  2. ^ "KENALOG IN ORABASE triamcinolone acetonide". Australian Register of Therapeutic Goods (ARTG). Australian Government. ARTG ID 19205.
  3. ^ "KENACORT A10 triamcinolone acetonide". Australian Register of Therapeutic Goods (ARTG).
  4. ^ "NASACORT AQ Triamcinolone acetonide". Annual charge exemptions dataset. Department of Health and Aged Care, Australian Government.
  5. ^ "Aristocort C Product information". Health Canada. 25 April 2012. Retrieved 23 December 2022.
  6. ^ "Nasacort Allergy 24HR Product information". Health Canada. 25 April 2012. Retrieved 23 December 2022.
  7. ^ "Adcortyl Intra-Articular/Intradermal Injection 10mg/ml - Summary of Product Characteristics (SmPC)". (emc). 8 October 2021. Retrieved 23 December 2022.
  8. ^ "Kenalog Intra-articular / Intramuscular Injection - Summary of Product Characteristics (SmPC)". (emc). 8 April 2022. Retrieved 23 December 2022.
  9. ^ "Nasacort 55 micrograms/dose, nasal spray, suspension - Summary of Product Characteristics (SmPC)". (emc). 1 November 2021. Retrieved 23 December 2022.
  10. ^ "Nasacort Allergy Relief for Adults 55 micrograms/dose, nasal spray, suspension - Summary of Product Characteristics (SmPC)". (emc). 1 November 2021. Retrieved 23 December 2022.
  11. ^ a b "Xipere- triamcinolone acetonide injection, suspension". DailyMed. Retrieved 19 December 2021.
  12. ^ "Active substance(s): triamcinolone (topical and nasal formulations)" (PDF). List of nationally authorised medicinal products. European Medicines Agency. 8 March 2018.
  13. ^ "Triamcinolone Topical". MedlinePlus. Retrieved 12 November 2020.
  14. ^ a b "Nasacort Allergy 24HR- triamcinolone acetonide spray, metered". DailyMed. 3 February 2014. Retrieved 12 November 2020.
  15. ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Retrieved 6 March 2023.
  16. ^ "Nystatin And Triamcinolone (Topical Route)". mayoclinic.org. Mayo Foundation for Medical Education and Research. Retrieved 18 May 2016.
  17. PMID 33206392
    .
  18. PMID 23440797
    .
  19. ^ "Intralesional Steroid Therapy (Patient Information Leaflets)". British Association of Dermatologists. 2008. Archived from the original on 15 March 2020. Retrieved 15 March 2020.
  20. PMID 5919603
    .
  21. PMID 26352007
    .
  22. ISBN 978-3-7741-9846-3
    .
  23. ^
    ISBN 978-3-642-60447-8
    .
  24. PMID 27874912
    .
  25. PMID 376542
    .
  26. PMID 7121132
    .
  27. ^
    ISBN 978-1-4757-2085-3
    .
  28. ^ Genesis (triamcinolone acetonide) Topical Spray Drug information
  29. ^ Champion Hurdle favorite Yanworth failed drug test

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Triamcinolone_acetonide&oldid=1214234276"