Trichoepithelioma
| Trichoepithelioma | |
|---|---|
| Other names | Brooke's tumour Epithelioma afenoides cysticum . |
 | |
| Micrograph of a trichoepithelioma. H&E stain. | |
| Specialty | Dermatology |
| Usual onset | usually young adults |
| Diagnostic method | Clinical history and examination are important. In a significant number of patients there is a familial trait. Examination will white, translucent, slightly raised papules which have a pearly white appearance. |
| Treatment | Any suspicicion of malignant change calls for adequate excision and histological examination. The only other reason for treatment is cosmetic . Partial destruction is usually followed by regrowth. Many treatment modalities may be used including surgical excision, curettage, cryotherapy and dermabrasion. High-energy pulsed carbon dioxide laser has also been advocated as a useful treatment. |
Trichoepithelioma is a
basal cell carcinoma
.
One form has been mapped to chromosome 9p21.[2]
Types
Trichoepitheliomas may be divided into the following types:[3]: 672
- Multiple familial trichoepithelioma
- Solitary trichoepithelioma
- Desmoplastic trichoepithelioma
Pathology
Trichoepitheliomas consists of nests of basaloid cells, with
Mitoses
are uncommon when compared to basal cell carcinoma.
Diagnosis
Trichoepiteliomas often contain Merkel cells; an immunostain for CK20 can be used to demonstrate this.[4]
See also
- Trichoblastoma
- Pilomatricoma
- CYLD cutaneous syndrome
- List of cutaneous conditions
- List of cutaneous neoplasms associated with systemic syndromes
References
- ^ "Trichoepithelioma: Overview - eMedicine Dermatology". Retrieved 2009-02-11.
- S2CID 16609272.
- ISBN 0-7216-2921-0.
- PMID 29072946.