Tricuspid regurgitation
Tricuspid regurgitation | |
---|---|
Other names | Tricuspid insufficiency |
Echocardiogram showing typical findings in severe tricuspid regurgitation | |
Specialty | Cardiology |
Symptoms | Ascites[1] |
Causes | Abnormally high blood pressure , other heart problem[2] |
Diagnostic method | Echocardiogram[2] |
Treatment | Diuretic, Surgery[2] |
Tricuspid regurgitation (TR), also called tricuspid insufficiency, is a type of
The causes of TR are divided into hereditary and acquired; and also primary and secondary. Primary TR refers to a defect solely in the tricuspid valve, such as
The mechanism of TR is either a dilatation of the base (annulus) of the valve due to right ventricular dilatation, which results in the three leaflets being too far apart to reach one another; or an abnormality of one or more of the three leaflets.[1]
Signs and symptoms
The symptoms of TR depend on its severity. Severe TR causes right-sided heart failure, with the development of ascites and peripheral edema.[1] In severe cases of right heart failure due to TR, venous congestion of the kidneys and liver may lead to cardiorenal syndrome (kidney failure secondary to heart failure) and cardiohepatic syndromes (liver failure secondary to heart failure) respectively.[3] Venous congestion from TR and right heart failure may also lead to anasarca (diffuse swelling) and decreased intestinal absorption due to the swelling surrounding the intestines, in severe cases this may lead to cachexia and malnutrition.[3]
A pansystolic
On examination of the neck, there may be giant C-V waves in the jugular pulse.[6] With severe TR, there may be an enlarged liver detected on palpation of the right upper quadrant of the abdomen; the liver may be pulsatile on palpation and even on inspection.[7]
Causes
The causes of TR may be classified as congenital
In regards to primary and secondary causes they are:[9]
- Primary causes
- Rheumatic
- Myxomatous
- Ebstein anomaly
- Endomyocardial fibrosis
- Endocarditis
- Traumatic (blunt chest injury)
- Secondary causes
- Left ventricular systolic dysfunction
- Mitral valve stenosis or regurgitation
- Chronic lung disease
- Pulmonary thromboembolism
- Myocardialdisease
- Right ventricular ischemia and infraction
- Left to right shunt
- Carcinoid heart disease
Mechanism
In terms of the mechanism of tricuspid insufficiency, it involves the expansion of the tricuspid
Diagnosis
The diagnosis of TR may be suspected if the typical murmur of TR is heard or other signs suggestive of right heart failure.[citation needed]
Definitive diagnosis is made by
Management
Medical
Medical therapy for tricuspid regurgitation consists of diuretics (
Surgical
Indications for surgical fixation of tricuspidal issues include organic lesion(s) in the valve or severe functional regurgitation. During open heart surgery for another issue (e.g. mitral valve), fixing the tricuspid valve may be considered, but medical consensus is unclear. Some argue that even mild to moderate tricuspid regurgitation should be addressed, while others take a more conservative approach. Infective endocarditis or traumatic lesions are other indications.[14]
Surgical options include annuloplasty or replacement of the valve. Adding a rigid prosthetic ring aims to decrease the diameter of the valve and stabilize it. Another annuloplasty modality is the "De Vega technique", in which the valve diameter is decreased by two sutures placed around the periphery of the valve. In cases of severe organic lesions of the valve, such as endocarditis, the valve may be excised. Tricuspid valve replacement with either a mechanical valve or a bioprosthesis may be indicated depending on the patient.[15] Mechanical prostheses can cause thromboembolic phenomena, while bioprostheses may degenerate with use.[11] Some evidence suggests that there is no significant difference between the survival rates of recipients of mechanical versus biological tricuspid valves.[16][15]
When controlled for severity of TR, tricuspid valve surgery performed on TR patients as considered appropriate is associated with improved outcomes (Hazard ratio= .74).[17]
Prognosis
The prognosis of TR is less favorable for females than males. Females are at a greater risk of progressing to severe TR as compared to males.[3] Survival rates are proportional to TR severity;[18] but even mild TR reduces survival compared to those with no TR. In some studies, the 1 year mortality rate of severe, medically treated TR is 36-42% with a 2-3.2 times increased risk of death in moderate or severe TR as compared to mild TR or no tricuspid valvular disease.[3] Even in those with mild TR, a large population based study showed about a 29% greater risk of death as compared to healthy controls.[19]
Epidemiology
In The
In a study of 595 male elite football players aged 18–38, and 47 sedentary non-athletes, it was found that 58% of the athletes had tricuspid regurgitation vs. 36% in non-athletes. Football players with tricuspid regurgitation had larger tricuspid annulus diameter, compared to athletes without tricuspid regurgitation. Athletes with tricuspid regurgitation also had enlarged right atrium diameter when compared to control group.[23]
See also
- Heart valves
References
- ^ a b c Tricuspid Regurgitation~clinical at eMedicine
- ^ a b c d MedlinePlus Encyclopedia: Tricuspid regurgitation
- ^ .
- ^ "Tricuspid Valve Disease & Tricuspid regurgitation (TR) | Patient". Patient. Retrieved 2015-12-14.
- ISBN 9780781741903.
- PMID 24224640.
- .
- PMID 24084288.
- PMID 19470900.
- PMID 20813321.
- ^ PMID 17228081.
- ^ Shah PM, Raney AA; Tricuspid valve disease. Curr Probl Cardiol. 2008 Feb33(2):47-84
- ^ Mestres, Bernal & Pomar 2016, chapter 81 Surgical Treatment of Tricuspid Valve Diseases#Indications for Surgery.
- ^ a b Mestres, Bernal & Pomar 2016, chapter 81 Surgical Treatment of Tricuspid Valve Diseases#Tricuspid Valve Surgery.
- ^ "BestBets: Should the tricuspid valve be replaced with a mechanical or biological valve?". www.bestbets.org. Retrieved 2015-12-14.
- PMID 29246545. – via ScienceDirect(Subscription may be required or content may be available in libraries.)
- PMID 15013122.
- .
- PMID 10190406.
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- PMID 26358570.
- PMID 26509381.
Sources
- Mestres, Carlos A.; Bernal, Jose M.; Pomar, Jose L. (2016). "Surgical Treatment of Tricuspid Valve Diseases". In Frank Sellke; ISBN 978-0-323-24126-7.
Further reading
- Haddad, F; Doyle, R; Murphy, D. J; Hunt, S. A (2008). "Right Ventricular Function in Cardiovascular Disease, Part II: Pathophysiology, Clinical Importance, and Management of Right Ventricular Failure". Circulation. 117 (13): 1717–1731. PMID 18378625.
- Desai, Ravi R; Vargas Abello, Lina Maria; Klein, Allan L; Marwick, Thomas H; Krasuski, Richard A; Ye, Ying; Nowicki, Edward R; Rajeswaran, Jeevanantham; Blackstone, Eugene H; Pettersson, Gösta B (2013). "Tricuspid regurgitation and right ventricular function after mitral valve surgery with or without concomitant tricuspid valve procedure". The Journal of Thoracic and Cardiovascular Surgery. 146 (5): 1126–1132.e10. PMID 23010580.
- Badano, Luigi P; Muraru, Denisa; Enriquez-Sarano, Maurice (2013). "Assessment of functional tricuspid regurgitation". European Heart Journal. 34 (25): 1875–1885. PMID 23303656.
- al.], Hugh D. Allen ... [et; Shaddy, Robert E.; Feltes, Timothy F. (2013). Moss and Adams heart disease in infants, children, and adolescents : including the fetus and young adult (8th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ISBN 9781451118933.