TICAM1
(Redirected from
Trif
)TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an
MyD88 adapter.[5]
chemokines as well as to upregulate the expression of immune cells. All TLRs have a TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to a given pathogen.[6]
Structure
TICAM1 is primarily active in the spleen and is often regulated when
TLR3 activation of NF-κB, indicating the use of the RIP1 gene in downstream TICAM1 activation, in contrast to other TLRs that use IRAK protein for the activation of NF-κB.[8]
Areas of research
Investigations into the function of TICAM1 are of great significance to various fields of biomedical research. The
tumor growth, and rheumatoid arthritis all have close ties with TLR signaling pathways, specifically to that of TICAM1 . Better understanding of the TICAM1 pathway will be therapeutically useful in the development of vaccines and treatments that can control associated inflammation and antiviral responses. Experiments involving wild-type and TICAM1-deficient mice are critical for understanding the coordinated responses of TLR pathways. It is necessary to study the coordinated effects of these pathways in order to understand the complex responses initiated by TICAM1.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127666 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047123 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 15379975.
- PMID 17327220.
- ^ Palsson-McDermott, Eva and Luke A J O’Neill (2004) Immunology. 113(2) 153-162
- ^ Kawai, Taro and Shizuo Akira. (2004). Arthritis Res. Ter. 7(1) 12-19
- PMID 17275788.
External links
- Toll-like receptor signaling pathway - Reference pathway (KO) from the KEGG website.
- TICAM1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)