Trimethadione

Source: Wikipedia, the free encyclopedia.
This article is about the drug Tridione. For the content management software Tridion, see SDL plc.
Trimethadione
Clinical data
Trade namesTridione
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • X
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Renal
Identifiers
  • 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione
JSmol)
  • O=C1N(C(=O)OC1(C)C)C
  • InChI=1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3 checkY
  • Key:IRYJRGCIQBGHIV-UHFFFAOYSA-N checkY
  (verify)

Trimethadione (Tridione) is an

epileptic
conditions that are resistant to other treatments.

It is primarily effective in treating

Steven Johnson syndrome, nephrotoxicity, hepatitis, aplastic anemia, neutropenia, or agranulocytosis. More common adverse effects include drowsiness, hemeralopia, and hiccups.[1][2]

Fetal trimethadione syndrome

If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth restriction (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[3]

References

  1. OCLC 1024170745
    .
  2. ISBN 978-0-39754-230-7
    .
  3. ^ Teratology and Drug Use During Pregnancy Retrieved January 2007

External links

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