Tropane alkaloid

Tropane alkaloids are a class of bicyclic [3.2.1]

Classification

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Anticholinergics

• racemic hyoscyamine, from the deadly nightshade (Atropa belladonna
  )
• Latua pubiflora
  ).
• Scopolamine, from henbane and Datura
  species (Jimson weed)

All three acetylcholine-inhibiting chemicals can also be found in the leaves, stems, and flowers in varying, unknown amounts in Brugmansia (angel trumpets), a relative of Datura. The same is also true of many other plants belonging to subfamily Solanoideae of the Solanaceae, the alkaloids being concentrated particularly in the leaves and seeds. However, the concentration of alkaloids can vary greatly, even from leaf to leaf and seed to seed.^[10][11]

Stimulants

Stimulants and cocaine-related alkaloids:

• Cocaine, from coca plant (Erythroxylum coca)
• Ecgonine, a precursor and metabolite of cocaine
• Benzoylecgonine, a metabolite of cocaine
• Hydroxytropacocaine, from coca plant (Erythroxylum coca)
• Methylecgonine cinnamate, from coca plant (Erythroxylum coca)

Others

• Catuabines, found in catuaba, an infusion or dry extract made from Erythroxylum vaccinifolium
• Scopine

Synthetic analogs of tropane alkaloids also exist, such as the phenyltropanes. They are not considered to be alkaloids per definition.

Biosynthesis

The biosynthesis of the tropane alkaloids have attracted intense interest because of their high physiological activity as well as the presence of the bicyclic tropane core.^[12]

References