Troparil
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Melting point | 190 to 191 °C (374 to 376 °F) |
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Troparil (also known as (–)-2β-Carbomethoxy-3β-phenyltropane, WIN 35,065-2, or β-CPT) is a
Background
The first known published synthesis of troparil and the related compound
Application
Phenyltropanes are likely to have less abuse and dependency compared with cocaine.[6][7]
Troparil is used in scientific research into the dopamine reuptake transporter. 3H-radiolabelled forms of troparil have been used in humans and animals to map the distribution of dopamine transporters in the brain.[8][9] It is also used for animal research into stimulant drugs as an alternative to cocaine which produces similar effects,[10] but avoids the stringent licensing requirements for the use of cocaine itself.
Troparil has similar effects to cocaine in animal studies,[11][12] but recreational use of this compound to date has proven extremely rare. Despite being easily made by the reaction of methylecgonidine with phenylmagnesium bromide,[5][13] the relative scarcity of methylecgonidine and the demanding reaction conditions required for the synthesis[14][15] put production of this compound beyond the capacity of most illicit drug manufacturers, and legitimate supplies of troparil are available only in very small quantities for a very high price.
Legality
The legal status of troparil is unclear, but it may be considered a
See also
References
- PMID 17017960.
- PMID 7830281.
- S2CID 70385136.
- ^ U.S. patent 3,813,404
- ^ PMID 4747968.
- PMID 15957006.
- PMID 17258302.
- S2CID 32490965.
- S2CID 43839331.
- PMID 3838516.
- PMID 1797525.
- PMID 9083474.
- PMID 2362282.
- .
- PMID 2033595.
- ^ "Controlled Drugs and Substances Act (S.C. 1996, c. 19)". Department of Justice. Government of Canada. Archived from the original on 7 January 2012.