Trough level
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In
cleared by the body, so the concentration of drug that remains available is dropping. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing.[3] A trough level is contrasted with a "peak level" (Cmax
), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is widely used in clinical trials for newer medicines to investigate therapeutic effectiveness and safety.
Ctrough is slightly different from Cmin, the minimum concentration during the time interval between administration of two doses.[1][2]
References
- ^ a b HJ Weimann (2003). "Drug concentrations and directly derived parameters". In W Cawello (ed.). Parameters for Compartment-Free Pharmacokinetics. Aachen: Shaker-Verlag. pp. 31–4.
- ^ a b AGAH working group Pharmacokinetics, 2004.
- ^ "Obtaining Trough Blood Levels" (PDF). University of Virginia Health System. 2007-03-29. Retrieved 2009-11-22. Archived version 2009-11-22
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