Tumid lupus erythematosus

Source: Wikipedia, the free encyclopedia.
Tumid lupus erythematosus
Other names"Lupus erythematosus tumidus"[1]
SpecialtyDermatology

Tumid lupus erythematosus is a rare, but distinctive entity in which patients present with edematous erythematous plaques, usually on the trunk.[2]

Lupus erythematosus tumidus (LET) was reported by

Topical corticosteroids are not effective as treatment for LET, but many will respond to chloroquine. LET resolves with normal skin, no residual scarring, no hyperpigmentation or hypopigmentation. Cigarette smokers who have LET may not respond very well to chloroquine.[4][5]

It has been suggested that it is equivalent to

Jessner lymphocytic infiltrate of the skin.[6]

Signs and symptoms

The characteristic presentation of tumid lupus erythematosus is erythematous, edematous plaques that lack ulceration or scaling.[4] In contrast to discoid lupus erythematosus (DLE), there is no atrophy, scarring, or follicular plugging. Skin exposed to the elements, such as the face, upper chest (V-neck distribution),  upper back, extensor arms, and shoulders, is typically affected by tumid lupus erythematosus.[7] Rare cases of tumid lupus erythematosus affecting the lower extremities have been documented, nevertheless.[8] Tumid lupus erythematosus typically manifests itself in the summer in temperate climates.[7]

periorbital edema are less frequent signs of tumid lupus erythematosus.[12]

Causes

There is currently no known unique etiology for tumid lupus erythematosus. However, it has been shown that triggering variables like ultraviolet (UV) exposure can exacerbate tumid lupus erythematosus lesions.

highly active antiretroviral therapy.[17][18]

Diagnosis

The identification of consistent clinical symptoms and histopathologic findings is the basis for the diagnosis of tumid lupus erythematosus. Provocative phototesting results and antimalarial medication response are additional tests that are not usually required but can confirm a diagnosis of tumid lupus erythematosus.[7]

Proposed diagnostic criteria reflect key findings in tumid lupus erythematosus:[4]

  1. Clinical - Smooth-surfaced, succulent, urticarial-like, erythematous plaques in sun-exposed areas.[4]
  2. Histologic - There is no epidermal involvement or modification of the dermoepidermal interface; instead, there is perivascular and periadnexal lymphocytic infiltration, interstitial mucin deposition, and, in certain instances, dispersed neutrophils.[4]
  3. Phototesting - Skin lesion proliferation following exposure to ultraviolet A (UVA) and/or ultraviolet B (UVB) radiation.[4]
  4. Treatment - Quick and efficient systemic antimalarial medication treatment.[4]

Treatment

First-line treatments include photoprotection, topical

folic acid supplements are examples of second-line therapy.[19] If all previous treatments are ineffective, third-line treatments such as thalidomide or lenalidomide may be considered.[4][20] Another effective treatment for suppressive, non-curative conditions is pulse dye laser.[21] In order to keep the lesions from relapsing in these patients, trigger avoidance measures including wearing sunscreen and abstaining from smoking are essential.[19]

See also

References

  1. ISBN 978-1-4160-2999-1
    .
  2. ISBN 0-7216-2921-0
    .
  3. ^ Gougerot H, Burnier R. Lupus érythémateux "tumidus". Bull Soc Fr Dermatol Syphiligr. 1930;37:1291-1292.
  4. ^
    PMID 10926740
    .
  5. PMID 12041952
    .
  6. ^ "Jessner Lymphocytic Infiltration of the Skin: eMedicine Dermatology". Retrieved 2010-05-22.
  7. ^ a b c "UpToDate". UpToDate. Retrieved 2024-03-02.
  8. PMID 18664992
    .
  9. S2CID 35133682
    .
  10. S2CID 27225913
    .
  11. PMID 1550369
    .
  12. S2CID 45610534
    .
  13. PMID 29494121
    . Retrieved 2024-03-02.
  14. PMID 28122678
    .
  15. S2CID 21127920
    .
  16. S2CID 30625226
    .
  17. S2CID 43483915
    .
  18. PMID 16415403
    .
  19. ^
    PMID 32607289
    .
  20. PMID 27981226
    .
  21. PMID 21957901
    .

Further reading

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Tumid_lupus_erythematosus&oldid=1211961177"