Tumor necrosis factor receptor 2
Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that binds
Function
The protein encoded by this gene is a member of the
Clinical significance
CNS
At least partly because TNFR2 has no intracellular death domain, TNFR2 is neuroprotective.[10]
Patients with schizophrenia have increased levels of soluble tumor necrosis factor receptor 2 (
Cancer
Targeting of TNRF2 in tumor cells is associated with increased tumor cell death and decreased progression of tumor cell growth.[8]
Increased expression of TNFR2 is found in breast cancer, cervical cancer, colon cancer, and renal cancer.[8] A link between the expression of TNRF2 in tumor cells and late-stage cancer has been discovered.[8] TNFR2 plays a significant role in tumor cell growth as it has been found that the loss of TNFR2 expression is linked with increased death of associated tumor cells and a significant standstill of further growth.[8] There is therapeutic potential in the targeting of TNFR2 for cancer treatments through TNFR2 inhibition.[12]
Systemic Lupus Erythematous (SLE)
A small scale study of 289 Japanese patients suggested a minor increased predisposition from an amino acid substitution of the 196 allele at exon 6. Genomic testing of 81
Interactions
TNFRSF1B has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000028137 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028599 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 36187863.
- PMID 8702885.
- ^ PMID 24350291.
- ^ PMID 29892300.
- ^ "Entrez Gene: TNFRSF1B tumor necrosis factor receptor superfamily, member 1B". Retrieved 8 May 2017.
- PMID 18774186.
- PMID 29529289.
- S2CID 75139844.
- PMID 10395102.
- S2CID 11683986.
- PMID 7639698.
- PMID 8702708.
- PMID 11907088.
- PMID 8710854.
- PMID 9162022.
- PMID 18671942.
- PMID 10764746.
Further reading
- Kollias G, PMID 12220546.
- Holtmann MH, Schuchmann M, Zeller G, Galle PR, Neurath MF (2003). "The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders". Archivum Immunologiae et Therapiae Experimentalis. 50 (4): 279–288. PMID 12371624.
- Horiuchi T, Kiyohara C, Tsukamoto H, Sawabe T, Furugo I, Yoshizawa S, et al. (March 2007). "A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis". Annals of the Rheumatic Diseases. 66 (3): 320–324. PMID 17028114.
External links
- CD120b+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)