Tumor necrosis factor superfamily

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Tumor necrosis factor superfamily
SCOP2
1tnf / SCOPe / SUPFAM
OPM superfamily292
OPM protein2hew
Membranome80
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
TNF
SCOP2
1tnr / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The tumor necrosis factor (TNF) superfamily is a

embryogenesis.[2][3]

The superfamily contains 19 members that bind to 29 members of TNF receptor superfamily.[4] An occurrence of orthologs in invertebrates hints at ancient origin of this superfamily in evolution.[2]

The PROSITE pattern of this superfamily is located in a beta sheet in the central section of the protein that is conserved across all members.

Members

There are 19 family members, numerically classified as TNFSF#, where # denotes the member number, sometimes followed by a letter.[4][2]

TNFSF# Name Synonyms Gene Function
1 Lymphotoxin alpha TNFβ, TNFSF1B LTA Induction of
tumorigenesis
2 Tumor necrosis factor TNFα, Dif, Necrosin, TNFSF1A, ... TNF Regulation of immune cells, induction of
tumorigenesis and viral replication and response to sepsis
3 Lymphotoxin beta TNFγ LTB Induction of
tumorigenesis
4 OX40 ligand CD252, Gp34, CD134L TNFSF4 Activation of T cell immune response by T cell costimulation
5
CD40 ligand
CD154, TRAP, Gp39, T-BAM CD40LG Regulation of adaptive immune response by activating antigen-presenting cell
6 Fas ligand CD178, APTL, CD95L FASLG Regulation of T cell homeostasis by induction of apoptosis
7 CD27 ligand CD70 CD70 Regulation of B cell activation and T cell homeostasis
8
CD30 ligand
CD153 TNFSF8 Induction of
B cells, prevention of autoimmunity
9
CD137 ligand
4-1 BBL TNFSF9
10
TNF-related apoptosis-inducing ligand
CD253, APO-2L TNFSF10 Inhibition of
tumorigenesis, induction of apoptosis
11 Receptor activator of nuclear factor kappa-Β ligand CD254, OPGL, TRANCE, ODF TNFSF11 Tissue growth (particularly bone regeneration and remodeling), dendritic cell maturation
12 TNF-related weak inducer of apoptosis APO-3L, DR3L TNFSF12 Regulation of angiogenesis, induction of apoptosis
13
A proliferation-inducing ligand
CD256, TALL-2, TRDL1 TNFSF13 Regulation of B cell development and plasma cell survival
13B B-cell activating factor CD257, BLyS, TALL-1, TNFSF20, ... TNFSF13B Stimulation of
B cell
proliferation and differentiation
14 LIGHT CD258, HVEML TNFSF14 Stimulation of T cell proliferation, apoptosis regulation
15 Vascular endothelial growth inhibitor TL1, TL-1A TNFSF15 Inhibition of angiogenesis
18 TNF superfamily member 18 GITRL, AITRL, TL-6 TNFSF18 Regulation of T cell survival
19 Ectodysplasin A ED1-A1, ED1-A2 EDA Development of ectodermal tissues

References

External links