Tumor necrosis factor superfamily
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Tumor necrosis factors
)Tumor necrosis factor superfamily | |||||||||
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OPM superfamily | 292 | ||||||||
OPM protein | 2hew | ||||||||
Membranome | 80 | ||||||||
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TNF | |||||||||
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The tumor necrosis factor (TNF) superfamily is a
The superfamily contains 19 members that bind to 29 members of TNF receptor superfamily.[4] An occurrence of orthologs in invertebrates hints at ancient origin of this superfamily in evolution.[2]
The PROSITE pattern of this superfamily is located in a beta sheet in the central section of the protein that is conserved across all members.
Members
There are 19 family members, numerically classified as TNFSF#, where # denotes the member number, sometimes followed by a letter.[4][2]
TNFSF# | Name | Synonyms | Gene | Function |
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1 | Lymphotoxin alpha | TNFβ, TNFSF1B | LTA | Induction of tumorigenesis
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2 | Tumor necrosis factor | TNFα, Dif, Necrosin, TNFSF1A, ... | TNF | Regulation of immune cells, induction of tumorigenesis and viral replication and response to sepsis
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3 | Lymphotoxin beta | TNFγ | LTB | Induction of tumorigenesis
|
4 | OX40 ligand | CD252, Gp34, CD134L | TNFSF4 | Activation of T cell immune response by T cell costimulation |
5 | CD40 ligand
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CD154, TRAP, Gp39, T-BAM | CD40LG | Regulation of adaptive immune response by activating antigen-presenting cell |
6 | Fas ligand | CD178, APTL, CD95L | FASLG | Regulation of T cell homeostasis by induction of apoptosis |
7 | CD27 ligand | CD70 | CD70 | Regulation of B cell activation and T cell homeostasis |
8 | CD30 ligand
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CD153 | TNFSF8 | Induction of B cells, prevention of autoimmunity
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9 | CD137 ligand
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4-1 BBL | TNFSF9 | |
10 | TNF-related apoptosis-inducing ligand
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CD253, APO-2L | TNFSF10 | Inhibition of tumorigenesis, induction of apoptosis
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11 | Receptor activator of nuclear factor kappa-Β ligand | CD254, OPGL, TRANCE, ODF | TNFSF11 | Tissue growth (particularly bone regeneration and remodeling), dendritic cell maturation |
12 | TNF-related weak inducer of apoptosis | APO-3L, DR3L | TNFSF12 | Regulation of angiogenesis, induction of apoptosis |
13 | A proliferation-inducing ligand
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CD256, TALL-2, TRDL1 | TNFSF13 | Regulation of B cell development and plasma cell survival |
13B | B-cell activating factor | CD257, BLyS, TALL-1, TNFSF20, ... | TNFSF13B | Stimulation of B cell proliferation and differentiation
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14 | LIGHT | CD258, HVEML | TNFSF14 | Stimulation of T cell proliferation, apoptosis regulation |
15 | Vascular endothelial growth inhibitor | TL1, TL-1A | TNFSF15 | Inhibition of angiogenesis |
18 | TNF superfamily member 18 | GITRL, AITRL, TL-6 | TNFSF18 | Regulation of T cell survival |
19 | Ectodysplasin A | ED1-A1, ED1-A2 | EDA | Development of ectodermal tissues |
References
External links
- Tumor+Necrosis+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- pex1 tumor necrosis factor gene