Type II cytokine receptor
| Type II cytokine receptor | |
|---|---|
| Identifiers | |
| Symbol | Type II cytokine receptor |
| Pfam clan | CL0159 |
| Membranome | 2 |
| Interferon gamma receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | IFNGR1 | ||||||||
SCOP2 | 1fg9 / SCOPe / SUPFAM | ||||||||
| |||||||||
| Interferon-alpha/beta receptor, fibronectin type III | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Interfer-bind | ||||||||
SCOP2 | 1n6u / SCOPe / SUPFAM | ||||||||
| |||||||||
Type II cytokine receptors, also commonly known as class II cytokine receptors, are
Structure
Typically type II cytokine receptors are
Type II cytokine receptors are tyrosine-kinase-linked receptors. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK family). Binding of the receptor typically leads to activation of the canonical JAK/STAT signaling pathway.[6]
Types
Type II cytokine receptors include those that bind
Interferon receptors
The interferon receptor is a molecule displayed on the surface of cells which interacts with extracellular interferons. Class II cytokine receptors bind type I, type II, and type III interferons. Type I interferons play important roles in both the adaptive and innate immune responses, prevent proliferation of pathogens, and have antiviral activities. Type II interferons help to modulate the immune system’s response to pathogens, and these interferons also respond to pathogens. Type III interferons induce a similar response to type I interferons, but their expression is limited to