U-50488

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U-50488
Ball-and-stick model of the U-50488 molecule
Identifiers
  • 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
JSmol)
  • CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
  • InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1 ☒N
  • Key:VQLPLYSROCPWFF-QZTJIDSGSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

U-50488 is a drug which acts as a highly selective

antitussive effects,[2] and reverses the memory impairment produced by anticholinergic drugs.[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.[4][5] This compound has never received FDA approval and there are no reported human cases in the literature involving an U-50488 overdose.[6]

See also

References

  1. S2CID 37011292
    .
  2. PMID 9232674
    .
  3. PMID 9819804
    .
  4. PMID 10396128
    .
  5. PMID 10616295
    .
  6. PMID 29441248
    .


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