UGCG
| UGCG | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 9: 111.9 – 111.94 Mb | Chr 4: 59.19 – 59.22 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene.[5][6][7]
Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.[7]
Interactions
UGCG has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000148154 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028381 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8643456.
- PMID 9605861.
- ^ a b "Entrez Gene: UGCG UDP-glucose ceramide glucosyltransferase".
- PMID 12873973.
Further reading
- Kohyama-Koganaya A, Hirabayashi Y (2002). "[Role of glucosylceramide synthase as negative regulator for ceramide]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 470–475. PMID 11915344.
- Matsuo N, Nomura T, Imokawa G (1992). "A rapid and simple assay method for UDP-glucose:ceramide glucosyltransferase". Biochim. Biophys. Acta. 1116 (2): 97–103. PMID 1533793.
- Ichikawa S, Sakiyama H, Suzuki G, et al. (1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 4638–4643. PMID 8901638.
- Watanabe R, Wu K, Paul P, et al. (1998). "Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation". J. Biol. Chem. 273 (16): 9651–9655. PMID 9545298.
- Tepper AD, Diks SH, van Blitterswijk WJ, Borst J (2000). "Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens". J. Biol. Chem. 275 (44): 34810–34817. PMID 10945987.
- Ogretmen B, Schady D, Usta J, et al. (2001). "Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells". J. Biol. Chem. 276 (27): 24901–24910. PMID 11335714.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. PMID 12477932.
- Di Sano F, Fazi B, Citro G, et al. (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–3865. PMID 12873973.
- Grazide S, Terrisse AD, Lerouge S, et al. (2004). "Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines". J. Biol. Chem. 279 (18): 18256–18261. PMID 14766899.
- Norris-Cervetto E, Callaghan R, Platt FM, et al. (2004). "Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells". J. Biol. Chem. 279 (39): 40412–40418. PMID 15263008.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. PMID 15489334.
- Turzanski J, Grundy M, Shang S, et al. (2005). "P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway". Exp. Hematol. 33 (1): 62–72. PMID 15661399.
- Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–163. S2CID 14394243.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. S2CID 4427026.
- Fazi B, Melino S, Di Sano F, et al. (2006). "Cloning, expression, and preliminary structural characterization of RTN-1C". Biochem. Biophys. Res. Commun. 342 (3): 881–886. PMID 16500619.
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