UH-232

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UH-232
Clinical data
ATC code
  • none
Identifiers
  • (1S,2R)-5-Methoxy-1-methyl-2-(N,N-propylamino)tetralin
JSmol)
  • CC2C(N(CCC)CCC)CCc1c2cccc1OC
  (verify)

UH-232 ((+)-UH232) is a drug which acts as a subtype selective mixed agonist-antagonist for dopamine receptors, acting as a weak partial agonist at the D3 subtype,[1] and an antagonist at D2Sh autoreceptors on dopaminergic nerve terminals.[2][3][4] It causes dopamine release in the brain and has a stimulant effect,[5][6][7] as well as blocking the behavioural effects of cocaine.[8] It may also serve as a 5-HT2A receptor agonist, based on animal studies.[9] It was investigated in clinical trials for the treatment of schizophrenia, but unexpectedly caused symptoms to become worse.[9]

(+)-AJ76

The N-monopropyl derivative (+)-AJ76 is an active metabolite of UH-232 and has practically identical effects.

(+)-AJ76, CAS# 85378-82-1, 13755572

See also

References

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