Ullmann condensation

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Ullmann condensation
Named after Fritz Ullmann
Reaction type Coupling reaction
Identifiers
Organic Chemistry Portal ullmann-reaction
RSC ontology ID RXNO:0000081

The Ullmann condensation or Ullmann-type reaction is the copper-promoted conversion of aryl halides to aryl ethers, aryl thioethers, aryl nitriles, and aryl amines. These reactions are examples of cross-coupling reactions.[1]

Ullmann-type reactions are comparable to

stoichiometric amounts of copper. Aryl halides are required to be activated by electron-withdrawing groups. Traditional Ullmann style reactions used "activated" copper powder, e.g. prepared in situ by the reduction of copper sulfate by zinc metal in hot water. The methodology improved with the introduction of soluble copper catalysts supported by diamines and acetylacetonate ligands.[1]

Ullmann ether synthesis: C-O coupling

Illustrative of the traditional Ullmann ether synthesis is the preparation of p-nitrophenyl phenyl ether from

O2NC6H4Cl + C6H5OH + KOH → O2NC6H4O−C6H5 + KCl + H2O

Copper is used as a catalyst, either in the form of the metal or copper salts. Modern arylations use soluble copper catalysts.[3]

Goldberg reaction: C-N coupling

A traditional Goldberg reaction involves reaction of an aniline with an aryl halide. The coupling of 2-chlorobenzoic acid and aniline is illustrative:[4]

C6H5NH2 + ClC6H4CO2H + KOH → C6H5N(H)−C6H4CO2H + KCl + H2O

A typical catalyst is formed from

phenanthroline. The reaction is an alternative to the Buchwald–Hartwig amination
reaction.

Aryl iodides are more reactive arylating agents than are aryl chlorides, following the usual pattern. Electron-withdrawing groups on the aryl halide also accelerate the coupling.[5]

Hurtley reaction: C-C coupling

The nucleophile can also be carbon including

malonic ester and other dicarbonyl compounds:[6]

Z2CH2 + BrC6H4CO2H + KOH → Z2C(H)−C6H4CO2H + KBr + H2O (Z = CO2H)

More modern Cu-catalyzed C-C cross-couplings utilize soluble copper complexes containing phenanthroline ligands.[7]

C–S coupling

The arylation of alkylthiolates proceeds by the intermediacy of cuprous thiolates.[8]

Mechanism of Ullmann-type reactions

In the case of Ullmann-type reactions (aminations, etherifications, etc. of aryl halides), the conversions involve copper(I) alkoxide, copper(I) amides, copper(I) thiolates. The copper(I) reagent can be generated in situ from the aryl halide and copper metal. Even copper(II) sources are effective under some circumstances. A number of innovations have been developed with regards to copper reagents.[1]

These copper(I) compounds subsequently react with the aryl halide in a net metathesis reaction:

Ar−X + CuOR → Ar−OR + CuX
Ar−X + CuSR → Ar−SR + CuX
Ar−X + CuNHR → Ar−NHR + CuX

In the case of C-N coupling, kinetic studies implicate oxidative addition reaction followed by reductive elimination from Cu(III) intermediates (Ln = one or more spectator ligands):[9]

ROCuAr(X)Ln → RO−Ar + CuLn

History

The Ullmann ether synthesis is named after its inventor, Fritz Ullmann.[10] The corresponding Goldberg reaction, is named after Irma Goldberg.[11] The Hurtley reaction, which involves C-C bond formation, is similarly named after its inventor.[6]

References