Urea-containing cream

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Urea-containing cream
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Urea, also known as carbamide-containing cream,[

nails.[3]

In adults side effects are generally few.[4] It may occasionally cause skin irritation.[1] Urea works in part by loosening dried skin.[5] Preparations generally contain 5 to 50% urea.[2][3]

over the counter.[3]

Medical uses

Urea cream is indicated for debridement and promotion of normal healing of skin areas with hyperkeratosis, particularly where healing is inhibited by local skin infection, skin necrosis, fibrinous or itching debris or eschar.[5] Specific condition with hyperkeratosis where urea cream is useful include:

Side effects

Common side effects of urea cream are:

  • Mild skin irritation[9]
  • Temporary burning sensation[9]
  • Stinging sensation[9]
  • Itching[9]

In severe cases, there can be an

urticaria, difficulty breathing and swelling of the mouth, face, lips, or tongue.[9]

Mechanism of action

Urea in low doses is a humectant while at high doses (above 20%) it causes breakdown of protein in the skin.[10]

Urea dissolves the

hyperkeratotic areas.[5] In nails, urea causes softening and eventually debridement of the nail plate.[5]

References

External links

  • "Urea". Drug Information Portal. U.S. National Library of Medicine.