Urinary system

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Urinary system
bladder where it is stored. In urination, urine flows through the urethra (longer in males, shorter in females) to exit the body
Details
Identifiers
Latinsystema urinarium
MeSHD014551
TA98A08.0.00.000
TA23357
FMA7159
Anatomical terminology]

The human urinary system, also known as the urinary tract or renal system, consists of the

nephrons. Following filtration of blood and further processing, wastes (in the form of urine) exit the kidney via the ureters, tubes made of smooth muscle fibres that propel urine towards the urinary bladder, where it is stored and subsequently expelled from the body by urination. The female and male urinary system are very similar, differing only in the length of the urethra.[2]

Urine is formed in the kidneys through a filtration of blood. The urine is then passed through the ureters to the bladder, where it is stored. During urination, the urine is passed from the bladder through the urethra to the outside of the body.

800–2,000 milliliters (mL) of urine are normally produced every day in a healthy human. This amount varies according to fluid intake and kidney function.

Structure

3D model of urinary system

The urinary system refers to the structures that produce and transport urine to the point of excretion. In the human urinary system there are two kidneys that are located between the dorsal body wall and parietal peritoneum on both the left and right sides.

The formation of urine begins within the functional unit of the kidney, the nephrons. Urine then flows through the nephrons, through a system of converging tubules called collecting ducts. These collecting ducts then join together to form the minor calyces, followed by the major calyces that ultimately join the renal pelvis. From here, urine continues its flow from the renal pelvis into the ureter, transporting urine into the urinary bladder. The anatomy of the human urinary system differs between males and females at the level of the urinary bladder. In males, the urethra begins at the internal urethral orifice in the trigone of the bladder, continues through the external urethral orifice, and then becomes the prostatic, membranous, bulbar, and penile urethra. Urine exits through the external urethral meatus. The female urethra is much shorter, beginning at the bladder neck and terminating in the vaginal vestibule.

Development

Microanatomy

Under microscopy, the urinary system is covered in a unique lining called

urothelium, a type of transitional epithelium. Unlike the epithelial
lining of most organs, transitional epithelium can flatten and distend. Urothelium covers most of the urinary system, including the renal pelvis, ureters, and bladder.

Function

The main functions of the urinary system and its components are to:

Urine formation

Average urine production in adult humans is about 1–2

litres (L) per day, depending on state of hydration, activity level, environmental factors, weight, and the individual's health. Producing too much or too little urine requires medical attention. Polyuria is a condition of excessive urine production (> 2.5 L/day). Conditions involving low output of urine are oliguria (< 400 mL/day) and anuria
(< 100 mL/day).

The first step in urine formation is the filtration of blood in the kidneys. In a healthy human, the kidney receives between 12 and 30% of cardiac output, but it averages about 20% or about 1.25 L/min.

The basic structural and functional unit of the kidney is the

sodium by filtering the blood, reabsorbing what is needed and excreting the rest as urine
.

In the first part of the nephron,

proteins and blood cells are prevented from passing through the filtration membrane. The amount of filtrate produced every minute is called the glomerular filtration rate
or GFR and amounts to 180 litres per day. About 99% of this filtrate is reabsorbed as it passes through the nephron and the remaining 1% becomes urine.

The urinary system is regulated by the

Regulation of concentration and volume

The urinary system is under influence of the circulatory system, nervous system, and endocrine system.

retention of water by increasing water reabsorption in the collecting ducts of the kidney nephron.[4] Vasopressin increases water permeability of the kidney's collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the kidney nephron collecting duct plasma membrane.[5]

Urination

Urination, also sometimes referred to as micturition, is the ejection of

urinary bladder to the outside of the body. Urine is ejected through the urethra from the penis or vulva in placental mammals and through the cloaca in other vertebrates. In healthy humans (and many other animals), the process of urination is under voluntary control. In infants, some elderly individuals, and those with neurological injury, urination may occur as an involuntary reflex. Physiologically, micturition involves coordination between the central, autonomic, and somatic nervous systems. Brain centers that regulate urination include the pontine micturition center, periaqueductal gray, and the cerebral cortex
.

Clinical significance

Urologic disease can involve congenital or acquired dysfunction of the urinary system. As an example, urinary tract obstruction is a urologic disease that can cause urinary retention.

Diseases of the kidney tissue are normally treated by

Gynecologists
may also treat female urinary incontinence.

Diseases of other bodily systems also have a direct effect on urogenital function. For instance, it has been shown that

diabetes mellitus sensitizes the kidney to the damaging effects of hypertension.[6]

Diabetes also can have a direct effect in urination due to peripheral neuropathies, which occur in some individuals with poorly controlled blood sugar levels.[7]

urge UI, than medications alone.[8][9] Pelvic floor exercises known as Kegel exercises can help in this condition by strengthening the pelvic floor. There can also be underlying medical reasons for urinary incontinence which are often treatable. In children, the condition is called enuresis
.

Some cancers also target the urinary system, including bladder cancer, kidney cancer, ureteral cancer, and urethral cancer. Due to the role and location of these organs, treatment is often complicated.[citation needed]

History

Kidney stones have been identified and recorded about as long as written historical records exist.[10] The urinary tract including the ureters, as well as their function to drain urine from the kidneys, has been described by Galen in the second century AD.[11]

The first to examine the ureter through an internal approach, called ureteroscopy, rather than surgery was

open surgical approaches within the urinary system employed during the preceding two millennia.[10]

See also

References

  1. ^ "The Urinary Tract & How It Works | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases.
  2. ^ C. Dugdale, David (16 September 2011). "Female urinary tract". MedLine Plus Medical Encyclopedia.
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  7. ^ "Peripheral Neuropathy". Patient UK. Retrieved 2014-03-20.
  8. S2CID 80659370. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: DOI inactive as of April 2024 (link
    )
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External links