Urokinase receptor
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Location (UCSC) | Chr 19: 43.65 – 43.67 Mb | Chr 7: 24.16 – 24.18 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
The Urokinase receptor, also known as urokinase plasminogen activator surface receptor (uPAR) or CD87 (Cluster of Differentiation 87), is a
Molecular characteristics
uPAR consists of three tandem
It has been possible to express uPAR recombinantly in
Physiological significance
uPAR is a part of the
Clinical significance
Soluble urokinase plasminogen activator receptor (suPAR) has been found to be a biomarker of inflammation.[10] Elevated suPAR is seen in chronic obstructive pulmonary disease, asthma, liver failure, heart failure, cardiovascular disease, and rheumatoid arthritis.[10] Smokers have significantly higher suPAR compared to non-smokers.[10]
Urokinase receptors have been found to be highly expressed on
The components of the plasminogen activation system have been found to be highly expressed in many
uPAR has been involved in various other non-proteolytic processes related to cancer, such as cell migration, cell cycle regulation, and cell adhesion.
Interactions
Urokinase receptor has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000011422 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046223 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 28326549.
- PMID 15861141.
- S2CID 39521660.
- ^ ViroGates. "What is suPAR". suPARnostic® by ViroGates. Retrieved 2021-09-27.
- PMID 19893210.
- ^ S2CID 32624995.
- PMID 32601490.
- PMID 32555459.
- PMID 30419600.
- PMID 11359936.
Further reading
- Ploug M (2003). "Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor". Current Pharmaceutical Design. 9 (19): 1499–528. PMID 12871065.
- Kjøller L (January 2002). "The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motility". Biological Chemistry. 383 (1): 5–19. S2CID 6125978.
- Chavakis T, Kanse SM, May AE, Preissner KT (April 2002). "Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation". Biochemical Society Transactions. 30 (2): 168–73. PMID 12023845.
- Ploug M, Gårdsvoll H, Jørgensen TJ, Lønborg Hansen L, Danø K (April 2002). "Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy". Biochemical Society Transactions. 30 (2): 177–83. PMID 12023847.
- Alfano M, Sidenius N, Blasi F, Poli G (November 2003). "The role of urokinase-type plasminogen activator (uPA)/uPA receptor in HIV-1 infection". Journal of Leukocyte Biology. 74 (5): 750–6. S2CID 8526093.
- Alfano D, Franco P, Vocca I, Gambi N, Pisa V, Mancini A, Caputi M, Carriero MV, Iaccarino I, Stoppelli MP (February 2005). "The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis". Thrombosis and Haemostasis. 93 (2): 205–11. S2CID 35517406.
External links
- PLAUR+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q03405 (Human Urokinase plasminogen activator surface receptor) at the PDBe-KB.