Urokinase receptor

Source: Wikipedia, the free encyclopedia.
PLAUR
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_001005376
NM_001005377
NM_001301037
NM_002659

NM_011113

RefSeq (protein)

NP_001005376
NP_001005377
NP_001287966
NP_002650

NP_035243

Location (UCSC)Chr 19: 43.65 – 43.67 MbChr 7: 24.16 – 24.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The Urokinase receptor, also known as urokinase plasminogen activator surface receptor (uPAR) or CD87 (Cluster of Differentiation 87), is a

glycosylphosphotidylinositol (GPI) anchor. uPAR was originally identified as a saturable binding site for urokinase
(also known as uPA) on the cell surface.

Molecular characteristics

uPAR consists of three tandem

membrane proteins
.

It has been possible to express uPAR recombinantly in

molecular weight
of 50–60 kDA.

Physiological significance

uPAR is a part of the

Clinical significance

Soluble urokinase plasminogen activator receptor (suPAR) has been found to be a biomarker of inflammation.[10] Elevated suPAR is seen in chronic obstructive pulmonary disease, asthma, liver failure, heart failure, cardiovascular disease, and rheumatoid arthritis.[10] Smokers have significantly higher suPAR compared to non-smokers.[10]

Urokinase receptors have been found to be highly expressed on

chimeric antigen receptor T cells to eliminate senescent cells in mice.[11][12]

The components of the plasminogen activation system have been found to be highly expressed in many

tumors, indicating that tumors are able to hijack the system, and use it in metastasis. Thus inhibitors of the various components of the plasminogen activation system have been sought as possible anticancer drugs.[13]

uPAR has been involved in various other non-proteolytic processes related to cancer, such as cell migration, cell cycle regulation, and cell adhesion.

Interactions

Urokinase receptor has been shown to

interact with LRP1.[14]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011422 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046223 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 28326549
    .
  6. .
  7. .
  8. ^ ViroGates. "What is suPAR". suPARnostic® by ViroGates. Retrieved 2021-09-27.
  9. PMID 19893210
    .
  10. ^ .
  11. .
  12. .
  13. .
  14. .

Further reading

External links