VAV1
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| Location (UCSC) | Chr 19: 6.77 – 6.86 Mb | Chr 17: 57.59 – 57.64 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.[5]
Function
The protein encoded by this
HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.[6]
Interactions
VAV1 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000141968 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034116 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9438848.
- ^ "Entrez Gene: VAV1 vav 1 oncogene".
- S2CID 40103095.
- PMID 11790798.
- ^ PMID 11331248.
- PMID 9200440.
- PMID 8649418.
- ^ PMID 10207103.
- ^ PMID 8900182.
- PMID 7809090.
- ^ S2CID 32632406.
- ^ PMID 9162069.
- PMID 7530656.
- PMID 8524317.
- PMID 11368773.
- PMID 12186560.
- PMID 9047237.
- PMID 8703037.
- ^ S2CID 38371954.
- PMID 10725744.
- PMID 10394361.
- PMID 12084069.
- PMID 8986718.
Further reading
- Romero F, Fischer S (1997). "Structure and function of vav". Cell. Signal. 8 (8): 545–53. PMID 9115846.
- Bustelo XR (2000). "Regulatory and Signaling Properties of the Vav Family". Mol. Cell. Biol. 20 (5): 1461–77. PMID 10669724.
- Geyer M, Fackler OT, Peterlin BM (2001). "Structure–function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. PMID 11463741.
- Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. S2CID 33749514.
- Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell". Current HIV/AIDS Reports. 1 (1): 47–53. S2CID 34731265.
- Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. PMID 16454711.
- Katzav S (2007). "Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies". Cancer Lett. 255 (2): 241–54. PMID 17590270.
- Bustelo XR, Barbacid M (1992). "Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells". Science. 256 (5060): 1196–9. S2CID 35071104.
- Adams JM, Houston H, Allen J, Lints T, Harvey R (1992). "The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization". Oncogene. 7 (4): 611–8. PMID 1565462.
- Katzav S, Cleveland JL, Heslop HE, Pulido D (1991). "Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential". Mol. Cell. Biol. 11 (4): 1912–20. PMID 2005887.
- Coppola J, Bryant S, Koda T, Conway D, Barbacid M (1991). "Mechanism of activation of the vav protooncogene". Cell Growth Differ. 2 (2): 95–105. PMID 2069873.
- Katzav S, Martin-Zanca D, Barbacid M (1989). "vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells". EMBO J. 8 (8): 2283–90. PMID 2477241.
- Ramos-Morales F, Romero F, Schweighoffer F, Bismuth G, Camonis J, Tortolero M, Fischer S (1995). "The proline-rich region of Vav binds to Grb2 and Grb3-3". Oncogene. 11 (8): 1665–9. PMID 7478592.
- Weng WK, Jarvis L, LeBien TW (1995). "Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors". J. Biol. Chem. 269 (51): 32514–21. PMID 7528218.
- Matsuguchi T, Inhorn RC, Carlesso N, Xu G, Druker B, Griffin JD (1995). "Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL". EMBO J. 14 (2): 257–65. PMID 7530656.
- Uddin S, Katzav S, White MF, Platanias LC (1995). "Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin". J. Biol. Chem. 270 (13): 7712–6. PMID 7535775.
- Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID 7651724.
- Clevenger CV, Ngo W, Sokol DL, Luger SM, Gewirtz AM (1995). "Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line". J. Biol. Chem. 270 (22): 13246–53. PMID 7768923.
- Katzav S, Sutherland M, Packham G, Yi T, Weiss A (1995). "The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav". J. Biol. Chem. 269 (51): 32579–85. PMID 7798261.
- Ye ZS, Baltimore D (1995). "Binding of Vav to Grb2 through dimerization of Src homology 3 domains". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12629–33. PMID 7809090.
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