Menthyl isovalerate
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IUPAC name
(1R,3R,4S)-p-Menthan-3-yl 3-methylbutanoate
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Systematic IUPAC name
(1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl 3-methylbutanoate | |
Other names
Validolum; Valofin; Validol; Menthoval
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Identifiers | |
3D model (
JSmol ) |
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ChemSpider | |
ECHA InfoCard
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100.036.766 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C15H28O2 | |
Molar mass | 240.387 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Menthyl isovalerate, also known as validolum, is the
It is produced by typical esterification procedures with usual catalysts such as HCl or H2SO4, and is rather slow, usually done for 20+hr at 100°C or a bit higher. Validol, the anxiety medication containing a roughly 25% solution of menthol in menthyl isovalerate is prepared essentially in one step, in which the amount of menthol added before conducting the acid catalysed esterification is in an excess such that the resulting solution of the yielded ester has around 25% menthol, simplifying the procedure. Work up might consist of several washings, including one with aqueous sodium bicarbonate to neutralize traces of acid catalyst and unreacted isovaleric acid, and distillation.[citation needed]
Medical use
In Poland, Bulgaria, Romania and the former Soviet Union states including Russia, menthyl isovalerate mixed with roughly 25% menthol is sold as an anxiolytic under various trade names including Extravalerianic, Validol, Valofin, and Menthoval.[2][3][4]
See also
References
- ^ Menthyl isovalerate
- ^ Russian Medications List and Possible Side Effects
- ^ "Farmak Product Information - Validol" (PDF). Archived from the original (PDF) on 2016-03-15. Retrieved 2013-04-05.
- PMID 9035841.