Valorphin

Source: Wikipedia, the free encyclopedia.
Valorphin
Names
IUPAC name
L-Valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutamine
Identifiers
3D model (
JSmol
)
ChemSpider
  • InChI=1S/C44H60N8O12/c1-22(2)35(45)40(59)50-36(23(3)4)41(60)49-32(19-25-12-14-27(54)15-13-25)43(62)52-18-8-11-33(52)39(58)48-31(20-26-21-46-29-10-7-6-9-28(26)29)38(57)51-37(24(5)53)42(61)47-30(44(63)64)16-17-34(55)56/h6-7,9-10,12-15,21-24,30-33,35-37,46,53-54H,8,11,16-20,45H2,1-5H3,(H,47,61)(H,48,58)(H,49,60)(H,50,59)(H,51,57)(H,55,56)(H,63,64)/t24-,30+,31+,32+,33+,35+,36+,37+/m1/s1
    Key: CNYWVXYFCKFXLL-NMUVPRMFSA-N
  • C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc4ccc(cc4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N)O
Properties
C44H61N9O11
Molar mass 892.024 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Valorphin, also known as VV-hemorphin-5, is a

tumor cells,[3][4][5][6] the mediation of which, because they are reversed by naloxone, appears to be dependent on the opioid receptors.[5]

See also

References

  1. ^
    S2CID 46078832
    .
  2. ^
    PMID 1356941
    .
  3. ^
    S2CID 44834813
    .
  4. ^
    S2CID 46177846
    .
  5. ^
    S2CID 11332853
    .
  6. PMID 15662114
    .
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