Valpromide
Names | |
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Preferred IUPAC name
2-Propylpentanamide[1] | |
Identifiers | |
3D model (
JSmol ) |
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ChEBI | |
ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard
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100.017.632 |
EC Number |
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KEGG | |
MeSH | dipropylacetamide |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C8H17NO | |
Molar mass | 143.230 g·mol−1 |
Appearance | White crystals |
Melting point | 125 °C (257 °F; 398 K) |
log P | 2.041 |
Pharmacology | |
N03AG02 (WHO) | |
Hazards | |
GHS labelling: | |
Warning | |
H302 | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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Related compounds | |
Related amides
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Valnoctamide |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Valpromide (marketed as Depamide by
sodium valproate and may be more effective at preventing febrile seizures. However, it is over one hundred times more potent as an inhibitor of liver microsomal epoxide hydrolase. This makes it incompatible with carbamazepine
and can affect the ability of the body to remove other toxins. Valpromide is no safer during pregnancy than valproic acid.
Valpromide is formed through the reaction of valproic acid and
acid chloride
.
In pure form, valpromide is a white crystalline powder and has a melting point 125–126 °C. It is soluble only in hot water. It is available on the market in some European countries.
See also
- Valproate pivoxil
- Valnoctamide
- Carbromide
- Ibrotamide
- M 25 [1186293-14-0] is also one of the compounds that has a reputation.
References
- The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.
- Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology by Bernard Testa, Joachim M. Mayer (2003). ISBN 3-906390-25-X.
- In Vitro Methods in Developmental Toxicology by Gary L Kimmel, Devendra M Kochhar, Baumann (1989). ISBN 0-8493-6919-3.
- ^ "dipropylacetamide - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 24 June 2005. Identification and Related Records. Retrieved 21 February 2012.