Valsartan/hydrochlorothiazide
Angiotensin II receptor antagonist | |
Hydrochlorothiazide | Thiazide diuretic |
---|---|
Clinical data | |
Trade names | Co-vasotec, Diovan HCT, Co-Diovan, others |
AHFS/Drugs.com | Professional Drug Facts |
MedlinePlus | a611032 |
License data | |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
PubChem CID | |
KEGG | |
CompTox Dashboard (EPA) | |
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Valsartan/hydrochlorothiazide, sold under the brand name Diovan HCT among others, is a medication used to treat
Common side effects include dizziness and headaches.
The combination was approved for medical use in the United States in 1998.
Structure–activity relationship
Valsartan has the structure that most ARBs have with the extended biphenyl group and tetrazole which mimics the carboxylate group as a bioisostere but is not held to the same metabolic inactivation. One special note about the molecule in terms of how it differs with other angiotensin receptor blockers, is that the molecule at the 2-prime position has a tetrazole, which has an acidic hydrogen attached to it.
Medical uses
High blood pressure
Valsartan and hydrochlorothiazide are both medications
Contraindications
The use of valsartan in pregnancy is avoided due to the potential risk of fetal toxicity.
Adverse effects
Side effects that are most often seen with this medication include dizziness,
Overdose
Cases of overdose are quite rare. In the event of an overdose people may experience severe hypotension, electrolyte imbalances or abnormal heart rhythms. People are advised to contact emergency services or a poison control centre and are treated based on symptoms.[2][14]
Interactions
There are a few types of medications that interact with valsartan. Combined use with nonsteroidal anti-inflammatory drugs (NSAID) such as naproxen or ibuprofen can result in kidney injury in people who are elderly, dehydrated, or have reduced kidney function.[2] One study conducted Lapi F., et al. found that there was no increased risk of kidney injury when only using either a diuretic or angiotensin receptor blocker with an NSAID but did find an increased risk when all three medications were used together.[15] Valsartan usage with angiotensin receptor blocker, ACE inhibitors, or aliskiren results in additive side effects.[12]
Pharmacology
Valsartan is an angiotensin II receptor blocker this class of drug competes with
Pharmacokinetics
Valsartan has an oral
References
- FDA. Retrieved 22 October 2023.
- ^ a b c d e f g h i j k l m n o "Diovan HCT- valsartan and hydrochlorothiazide tablet, film coated". DailyMed. Retrieved 20 January 2021.
- ^ "Active substance: valsartan, hydrochlorothiazide / valsartan" (PDF). List of nationally authorised medicinal products. European Medicines Agency. 14 January 2021.
- ^ "Dafiro HCT EPAR". European Medicines Agency (EMA). Retrieved 21 April 2021.
- ^ "Exforge HCT EPAR". European Medicines Agency (EMA). Retrieved 21 April 2021.
- ^ ISBN 9780857113382.
- ^ a b c d "Hydrochlorothiazide and valsartan Uses, Side Effects & Warnings". Drugs.com. Retrieved 10 March 2019.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Hydrochlorothiazide; Valsartan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ^ "VIII. Choice of therapy for adults with hypertension without compelling indications for specific agents". Hypertension Canada. Retrieved 21 April 2021.
- ISBN 9781496349620.
- ^ a b c d e f g "Drug Product Database Online Query". Health Canada. 25 April 2012. Retrieved 22 April 2021.
- ^ S2CID 207490609.
- ^ "Valsartan/Hydrochlorothiazide - Oral". HealthLink BC. Retrieved 23 April 2021.
- PMID 23299844.
- ^ ISBN 978-0321981226.
- PMID 28613517. Retrieved 23 April 2021.
- ^ a b c "Valsartan". PubChem. U.S. National Library of Medicine. Retrieved 23 April 2021.
- ^ "Hydrochlorothiazide". PubChem. U.S. National Library of Medicine. Retrieved 23 April 2021.