Vasoactive intestinal peptide receptor
Chr. 3 p22 | |||||||
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Chr. 7 q36.3 | |||||||
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Chr. 7 p14 | |||||||
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There are two known
pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor
family.
T-lymphocytes
.
testis, and stomach
.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27,
peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.[3]
References
- PMID 12529932.
- S2CID 21588275.
- ^ "VIP and PACAP receptors". IUPHAR Guide to Pharmacology. The British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR).
External links
- "VIP and PACAP Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
- Receptors,+Vasoactive+Intestinal+Peptide at the U.S. National Library of Medicine Medical Subject Headings (MeSH)