Vesiculovirus matrix proteins
This article includes a list of general references, but it lacks sufficient corresponding inline citations. (September 2012) |
Vesiculo_matrix | |||||||||
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OPM superfamily | 381 | ||||||||
OPM protein | 1lg7 | ||||||||
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The family of vesiculovirus matrix proteins consists of several
activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein.[1]
Function
These proteins play a major role in assembly and budding of VSIV virions.mRNA nuclear export through direct interaction with the host RAE1-NUP98 complex. This inhibits interferon signaling and thus establishment of antiviral state in virus infected cells. In turn, this induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell. Enveloped viruses acquire their membrane by budding at a membrane of their host cell.[3]
Structure
The structure of these matrix proteins has revealed a single-globular domain with a new fold. The N-terminal part consists of a large five-stranded anti-parallel
C-terminal
part comprises a small two stranded anti-parallel beta-sheet and an alpha-helix.