Viminol
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Trade names | Dividol |
Other names | Dividol, viminolo, diviminol |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Identifiers | |
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JSmol) | |
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Viminol (marketed under the
brandname Dividol) is an opioid analgesic developed by a team at the drug company Zambon in the 1960s.[1] Viminol is based on the α-pyrryl-2-aminoethanol structure, unlike any other class of opioids.[2][3]
Viminol has both
agonist–antagonist profile similar to that of opioids such as pentazocine, although with somewhat fewer side effects.[6]
Side effects
Side effects are similar to other opioids, and can include:[medical citation needed]
However, since viminol is supplied as a racemic mixture of agonist and antagonist isomers, the
abuse potential and respiratory depression tends to be less than that of μ-opioid full agonist drugs.[medical citation needed
]
Drug dependence may occur.[7]
Related compounds
Later work showed that replacing the chlorine atom with an fluorine atom (trifluoromethyl group produced a compound with twice the potency and half the acute toxicity.[8] A later team at Zambon found that one isomer of a pyrrolidone analog is 318 times as potent as morphine in its analgesic activity in animal studies.[9] A number of related compounds were also found to be active, allowing a QSAR model to be constructed.
References
- ^ US 3539589, Teotino UM, Bella DD, "1-(α-Pyrryl)-2-amino Ethanols", issued 10 November 1970, assigned to Whitefin Holding SA
- PMID 6894429.
- PMID 609773.
- ^ US 3857857, Della D, Bella CV, Monza DC, Tiotino UM, "Stereoisomers of 1(1'(-O-Chlorobenzyl)-2'-Pyrryl)-2-Disec.Butylamino-Ethanol", issued 31 December 1974, assigned to Whitefin Holding SA
- S2CID 11418389.
- PMID 3525423.
- S2CID 71184621.
- ^ US 4148907, Conti F, "Stereoisomers of 1-(1'benzyl-2'pyrryl)-2-di-sec.-butylaminoethanol and pharmaceutical compositions comprising same", issued 10 April 1979, assigned to Etablissement Viridis
- ^ US 4960788, Carenzi A, Chiarino D, Bella DD, Grancini GC, Veneziani C, "Pyrrolidone-2 compounds and their use for central analgesic activity", issued 2 October 1990, assigned to Zambon Group S.P.A.
- .