Vinca alkaloid
Vinca alkaloids are a set of
beta-tubulin
polymerization in a dividing cell.
Sources
The Madagascan periwinkle N-bromosuccinimide and trifluoroacetic acid followed by silver tetrafluoroborate to yield vinorelbine.[10]
Applications
Vinca alkaloids are used in
cellular division.[13] The vinca alkaloids thus prevent microtubule polymerization, as opposed to the mechanism of action of taxanes
.
Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. These compounds include vinblastine, vincristine, vindesine, and vinorelbine. Additional researched vinca alkaloids include vincaminol, vineridine, and vinburnine.
ethyl ester of apovincamine").[14]
Minor vinca alkaloids include minovincine, methoxyminovincine, minovincinine, vincadifformine, desoxyvincaminol, and vincamajine.[15][16][17]
References
- PMID 15032608.
- ISBN 9783540563914.
- PMID 25586069.
- PMID 15141084.
- ISBN 9783540728795.
- ISBN 9781498704304.
- ^ PMID 22609781.
- ISBN 9783527326693.
- PMID 21695100.
- ^ PMID 19072542.
- ^ PMID 11922805.
- hdl:10481/47295.
- ISBN 978-1-891483-62-2. Archived from the originalon 2009-05-15. Retrieved 2011-05-26.
- PMID 1037211.
- PMID 13943964.
- S2CID 93210480.
- PMID 13619121.