Vincamine
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Trade names | Oxybral SR |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
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JSmol) | |
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Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor (lesser periwinkle), comprising about 25–65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids.[1]
Uses
Vincamine is sold in Europe as a prescription medicine for the treatment of primary degenerative and vascular dementia.[
Chemistry
Synthesis
Tabersonine can be used for semi-synthesis of vincamine.[3]
Derivatives
Vinpocetine is a synthetic derivative of vincamine used for cerebrovascular diseases and as dietary supplement.[4] Vincamine derivatives have been also studied as anti addictive[5] and antidiabetic[6] agents.
Research
It may have nootropic effects.[3] It has been investigated as novel anticancer drug.[7]
Concerns over long-term use have been documented by the US National Toxicology Program.[8]
See also
References
- ISBN 3-527-20100-9.
- ^ "Summary of Data for Chemical Selection: Vincamine" (PDF). National Toxicology Program. U.S. Department of Health and Human Services.
- ^ ISSN 0169-345X.
- ^ "Vinpocetine in Dietary Supplements". FDA. 2019-06-03.
- PMID 31913038.
- S2CID 210133217.
- S2CID 231624167.
- ^ "Vincamine Dietary Supplements 1617-90-9 - National Toxicology Program" (PDF). National Institute of Environmental Health Sciences. Retrieved 4 December 2023.
External links
- "Vincamine MSDS" (PDF). Archived from the original (PDF) on 2015-06-08. Retrieved 2012-01-30.
- Chemical Selection Working Group. "Vincamine - 1617-90-9" (PDF). Summary of Data for Chemical Selection. NIH - United States National Institutes of Health. Archived (PDF) from the original on 2011-10-21. Retrieved 2007-04-23.