ViroPharma

Add links
Source: Wikipedia, the free encyclopedia.

ViroPharma Incorporated
Number of employees
232[1]
Websitewww.viropharma.com

ViroPharma Incorporated was a

pharmaceutical company that developed and sold drugs that addressed serious diseases treated by physician specialists and in hospital settings. The company focused on product development activities on viruses and human disease, including those caused by cytomegalovirus (CMV) and hepatitis C virus (HCV) infections. It was purchased by Shire in 2013, with Shire paying around $4.2 billion for the company in a deal that was finalized in January 2014.[2] ViroPharma was a member of the NASDAQ Biotechnology Index and the S&P 600
.

The company had strategic relationships with

Sanofi-Aventis. ViroPharma acquired Lev Pharmaceuticals in a merger in 2008.[3][4]

History

ViroPharma Incorporated was founded in 1994 by Claude H. Nash (Chief Executive Officer), Mark A. McKinlay (Vice President, Research & Development), Marc S. Collett (Vice President, Discovery Research), Johanna A. Griffin (Vice President, Business Development), and Guy D. Diana (Vice President, Chemistry Research.) None of the founders are still with the company.

In November 2014,

Shire plc acquired ViroPharma for $4.2 billion.[5]

Products

Marketed products

Clostridium difficile
.

Pipeline

fast track status for maribavir.[7][8]

In March 2006, the company announced that a

statistically significantly reduced (p-value = 0.051 to 0.001) in each of the maribavir groups compared to the placebo group (57% for placebo
vs. 15%, 30%, and 15% for maribavir 100 mg twice daily, 400 mg daily, and 400 mg twice daily, respectively).

ViroPharma conducted a

prophylactic use for the prevention of cytomegalovirus disease in recipients of allogeneic stem cell transplant patients. In February 2009, ViroPharma announced that the Phase III study failed to achieve its goal, showing no significant difference between maribavir and a placebo in reducing the rate of CMV disease.[9]

Failed products

Main article: Pleconaril

Sanofi in 1995. Pleconaril is active against viruses in the picornavirus family. ViroPharma's first indication was for enteroviral meningitis, but that indication was abandoned when the clinical trials
did not demonstrate efficacy.

In 2001, ViroPharma submitted a New Drug Application of pleconaril to the FDA for the common cold.[10] On 2002-03-19, the FDA Antiviral Advisory Committee recommended that the company had failed to show adequate safety, and the FDA subsequently issued a not-approvable letter.[11]

In November 2004, ViroPharma licensed pleconaril to Schering-Plough,[12] who are developing an intranasal formulation for the common cold and asthma exacerbations. (Schering-Plough Development Pipeline). In August 2006, Schering-Plough started a Phase II clinical trial.

References

  1. ^ "Symbol Lookup from Yahoo Finance". finance.yahoo.com.
  2. ^ "Shire acquires ViroPharma for $4.2bn". Financier Worldwide. Retrieved 23 April 2020.
  3. ISSN 1937-8661
    . Retrieved 26 September 2008.
  4. ^ "Lev Pharmaceuticals Investor Relations". Lev Pharmaceuticals. Retrieved 8 April 2009.
  5. ^ Kitamura, Makiko (11 November 2013). "Shire Buys ViroPharma for $4.2 Billion to Add Orphan Drug". Bloomberg.
  6. ^ Pollack, Andrew (9 November 2005). "Crucial Antibiotic Rescues Biotech Maker's Finances". The New York Times. Retrieved 20 September 2007.
  7. ^ "FDA GRANTS FAST-TRACK STATUS FOR VIROPHARMA'S MARIBAVIR". www.fdanews.com. Retrieved 19 August 2020.
  8. ^ "FDA grants fast track status for ViroPharma's Maribavir | health.am". Retrieved 19 August 2020.
  9. ^ ViroPharma:Maribavir Phase III Study Missed Goal;Shares Plunge Archived 12 February 2009 at the Wayback Machine, CNN Money, 9 February 2009
  10. ^ Freundlich, Naomi (3 February 2002). "On the Trail of a Cure For the Common Cold". The New York Times. Retrieved 20 September 2007.
  11. ^ Pollack, Andrew (20 March 2002). "F.D.A. Panel Opposes Drug Meant to Treat Cause of Colds". The New York Times. Retrieved 20 September 2007.
  12. ^ "Picornaviruses and Schering-Plough" (PDF). Retrieved 23 December 2023.

Further references

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=ViroPharma&oldid=1191411022"