Visilizumab
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Visilizumab (tentative trade name Nuvion, PDL BioPharma Inc.) is a
humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease. Visilizumab binds to the CD3 receptor on certain activated T cells without affecting resting T cells. It is currently under clinical studies for the treatment of ulcerative colitis and Crohn's disease.[1]
PDL BioPharma, Inc. canceled production of visilizumab following its Phase II/III
.Visilizumab has also been
radiolabelled with technetium-99m for imaging T cells.[6]
References
- ^ "PDL BioPharma, Development Pipeline - Nuvion (visilizumab)". Archived from the original on 2007-09-15. Retrieved 2008-02-11.
- ^ "PDL Lands in a Hazard". 29 August 2007. Retrieved 2009-05-27.
- ^ Clinical trial number NCT00938626 for "Treated T Cells Followed by a Stem Cell Transplant in Treating Patients With Multiple Myeloma" at ClinicalTrials.gov
- S2CID 36595661.
- ^ Clinical trial number NCT00378508 for "Anti-CD3 mAb Treatment of Recent Onset Type 1 Diabetes" at ClinicalTrials.gov
- S2CID 31980716.
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