Vitamin-K-epoxide reductase (warfarin-insensitive)
| vitamin-K-epoxide reductase (warfarin-insensitive) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In
enzymology, a vitamin-K-epoxide reductase (warfarin-insensitive) (EC 1.17.4.5) is an enzyme that catalyzes the chemical reaction
- 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
Thus, the two
1,4-dithiothreitol
.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH or CH2 groups of donor with a disulfide as acceptor. The systematic name of this enzyme class is 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithi othreitol oxidoreductase.
References
- Mukharji I, Silverman RB (1985). "Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone". Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2713–7. PMID 3857611.
