Weber's syndrome
| Weber's syndrome | |
|---|---|
| Other names | Midbrain stroke syndrome Superior alternating hemiplegia |
 | |
| Midbrain cross section showing lesion | |
| Specialty | Neurology |
| Treatment | anything which can decrease the stroke's effect |
Weber's syndrome, also known as midbrain stroke syndrome or superior alternating hemiplegia, is a form of stroke that affects the medial portion of the midbrain. It involves oculomotor fascicles in the interpeduncular cisterns and cerebral peduncle so it characterizes the presence of an ipsilateral lower motor neuron type oculomotor nerve palsy and contralateral hemiparesis or hemiplegia.
Cause
It is mainly caused by a midbrain infarction as a result of occlusion of a branch of posterior cerebral artery most commonly or the paramedian branches of basilar bifurcation perforating arteries.[1][2]
This lesion is usually unilateral and affects several structures in the midbrain including:
| Structure damaged | Effect |
|---|---|
| substantia nigra | contralateral parkinsonism because its dopaminergic projections to the basal ganglia innervate the ipsilateral hemisphere motor field, leading to a movement disorder of the contralateral body.
|
corticospinal fibers
|
contralateral hemiparesis (if lateral corticospinal tract is only affected) & contralateral hemiplegia (if both lateral & anterior corticospinal tracts are affected) and typical upper motor neuron findings. It is contralateral because it occurs before the decussation in the medulla. |
corticobulbar tract
|
difficulty with contralateral lower facial muscles and hypoglossal nerve functions. |
| oculomotor nerve fibers | ipsilateral lower motor neuron type oculomotor nerve palsy with a drooping eyelid (partial ptosis) and fixed wide pupil pointed down and out (mydriasis). This leads to diplopia .
|
Diagnosis
Clinical findings mainly eyeball is down and out ipsilateral lateral squint. Ptosis present as the levator palpebrae superioris nerve supply is disrupted. Pupil dilated and fixed. Contralateral hemiplegia CT scan or MRI might help in delineating the cause or the vessel or region of brain involved in stroke.[citation needed]
Management
![[icon]](/File:Wiki_letter_w_cropped.svg){kind=small} | This section is empty. You can help by adding to it. (November 2017) |
History
It carries the name of Sir
See also
- Alternating hemiplegia of childhood
- Lateral medullary syndrome
- Lateral pontine syndrome
- Medial medullary syndrome
- Medial pontine syndrome
References
- ^ "Weber's syndrome". GPnotebook.
- ^ "Weber Syndrome". StatPearls. StatPearls. 2021.
- PMID 20896209.
- Who Named It?