Wellcome Trust Case Control Consortium

Source: Wikipedia, the free encyclopedia.

The Wellcome Trust Case Control Consortium (abbreviated WTCCC) is a collaboration between fifty research groups in the

loci for common human diseases.[3]

The consortium's initial goal was to conduct large GWASs for eight common human diseases:

coronary heart disease, type 1 diabetes, type 2 diabetes, rheumatoid arthritis, Crohn's disease and ulcerative colitis, bipolar disorder and hypertension. These GWASs included a total of 19,000 subjects, of whom 2,000 had one of the eight diseases and an additional 3,000 served as controls.[2] The study participants were genotyped using Affymetrix's GeneChip Human Mapping 500K Array Set, and genotype calling was conducted with the Chiamo algorithm.[4]

The results of the WTCCC's initial research were reported in

statistically significant at P < 5 × 10−7.[5][6] At the time, this was the largest study ever conducted of the genetics of human diseases.[7] In announcing the study's findings at a London news conference, Donnelly said, "If you think of the genome as a very long road that you are trying to find your way along in the dark, previously we have only been able to turn lights on in a small number of places, but now we can turn on lights in a large number of places— in this case half a million lights".[8] The 2007 Nature paper was later named "paper of the year" by the Lancet,[9] and it led to the WTCCC being named "research leader of the year" by Scientific American.[10]

References

  1. ^ "Wellcome Trust Case Control Consortium". University College London. Retrieved 23 November 2018.
  2. ^ a b "Researchers set to find 'genetic signposts' for eight diseases" (Press release). Wellcome Trust Case Control Consortium. 28 September 2005. Retrieved 23 November 2018.
  3. ^ "Wellcome Trust Case Control Consortium website". Retrieved 23 November 2018.
  4. PMID 18224336
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  5. .
  6. .
  7. ^ "Largest ever study of genetics of common diseases published today". Wellcome Trust (Press release). 6 June 2007. Retrieved 23 November 2018.
  8. ^ "Genes linked to 7 common diseases". CBC News. 7 June 2007. Retrieved 23 November 2018.
  9. S2CID 53251471
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  10. .

External links