XK (protein)
| XK (protein) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | XK | ||||||
| Alt. symbols | XKR1, Kx, X1k | ||||||
Chr. X p21.2-p21.1 | |||||||
| |||||||
XK (also known as Kell blood group precursor) is a
red blood cells and other tissues which is responsible for the Kx antigen which helps determine a person's blood type
.
Clinical significance
The Kx antigen plays a role in matching blood for blood transfusions.[citation needed]
Mutation of XK protein may lead to McLeod syndrome,[1] a multi-system disorder characterized by hemolytic anemia, myopathy, acanthocytosis, and chorea.[2]
XK is located on the X chromosome (cytogenetic band Xp21.1) and absence of the XK protein is an X-linked disease.[3]
Function
XK is a membrane transport protein of unknown action.[4]
References
External links
- GeneReviews/NCBI/NIH/UW entry on McLeod Neuroacanthocytosis Syndrome
- XK at NIH
- XK+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)