Yoshinori Ohsumi
Yoshinori Ohsumi | |
---|---|
Gairdner Foundation International Award (2015) Nobel Prize in Physiology or Medicine (2016) Breakthrough Prize in Life Sciences (2017) | |
Scientific career | |
Fields | Cell biologist |
Institutions | Tokyo Institute of Technology |
Website | www |
Yoshinori Ohsumi (大隅 良典, Ōsumi Yoshinori, born February 9, 1945) is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components. Ohsumi is a professor at Tokyo Institute of Technology's Institute of Innovative Research.[1] He received the Kyoto Prize for Basic Sciences in 2012,[2] the 2016 Nobel Prize in Physiology or Medicine, and the 2017 Breakthrough Prize in Life Sciences[3] for his discoveries of mechanisms for autophagy.[4]
Biography
Ohsumi was born on February 9, 1945, in
He returned to the University of Tokyo in 1977 as a
Christian de Duve coined the term autophagy in 1963 whereas Ohsumi began his work in 1988. Prior to that time, less than 20 papers per year were published on this subject.[6] During the 1990s, Ohsumi's group described the morphology of autophagy in yeast, and performed mutational screening on yeast cells that identified essential genes for cells to be capable of autophagy.[7][8]
In 2016, he was awarded the Nobel Prize in Physiology or Medicine "for his discoveries of mechanisms for autophagy".[9][10] He is the 25th Japanese person to be awarded a Nobel Prize.[11] Ohsumi's spouse Mariko, a Professor of Teikyo University of Science, collaborated on his research.[12] She is a co-author of many academic papers with him.[13]
Recognition
Source:[5]
- 2005 – Fujihara Award, Fujihara Foundation of Science
- 2006 – Japan Academy Prize, Japan Academy
- 2007 – Science Award, Botanical Society of Japan
- 2008 – Asahi Shimbun
- 2012 – Kyoto Prize in Basic Sciences[14]
- 2013 – Thomson Reuters Citation Laureate
- 2015 – Gairdner Foundation International Award
- 2015 – International Prize for Biology
- 2015 – Keio Medical Science Prize
- 2015 – Person of Cultural Merit
- 2015 – Rosenstiel Award
- 2016 – Wiley Prize in Biomedical Sciences
- 2016 – Dr. Paul Janssen Award for Biomedical Research
- 2016 – Nobel Prize in Physiology or Medicine[15]
- 2017 – Breakthrough Prize in Life Sciences[16]
Selected publications
His original findings about autophagy in yeast cells:[17]
- Takeshige K; Baba M; Tsuboi S; Noda T; Ohsumi Y (October 1992). "Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction". Wikidata Q29614187.
Follow up with more research on yeast:[17]
- Baba M; Takeshige K; Baba N; Ohsumi Y (March 1, 1994). "Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization". Wikidata Q34337565.
Others
- M Tsukada; Y Ohsumi (October 25, 1993). "Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae". Wikidata Q27935838.
- N Mizushima; T Noda; T Yoshimori; et al. (September 24, 1998). "A protein conjugation system essential for autophagy". Wikidata Q27940154.
- Y Kabeya; N Mizushima; T Ueno; et al. (November 1, 2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing". Wikidata Q24597817.
- Y Ichimura; T Kirisako; T Takao; et al. (November 23, 2000). "A ubiquitin-like system mediates protein lipidation". Wikidata Q27934137.
- Y Ohsumi (March 2001). "Molecular dissection of autophagy: two ubiquitin-like systems". Wikidata Q28206420.
- Kuma A; Hatano M; Matsui M; et al. (December 23, 2004). "The role of autophagy during the early neonatal starvation period". Wikidata Q29547489.
- Sho W Suzuki; Jun Onodera; Yoshinori Ohsumi (2011). "Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction". Wikidata Q27077073.
- Takao Hanada; Nobuo N Noda; Yoshinori Satomi; Yoshinobu Ichimura; Yuko Fujioka; Toshifumi Takao; Fuyuhiko Inagaki; Yoshinori Ohsumi (December 28, 2007). "The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy". Wikidata Q27933717.
- Michitaro Shibata; Kazusato Oikawa; Kohki Yoshimoto; et al. (December 24, 2013). "Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis". Wikidata Q34394370.
- Hayashi Yamamoto; Takayuki Shima; Masaya Yamaguchi; et al. (October 6, 2015). "The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy". Wikidata Q34497110.
- Hayashi Yamamoto; Yuko Fujioka; Sho W Suzuki; et al. (July 11, 2016). "The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes". Wikidata Q27718642.
See also
- List of Japanese Nobel laureates
- List of Nobel laureates affiliated with the University of Tokyo
References
- ^ ORCID 0000-0003-2384-2166
- ^ Biemiller, Lawrence (November 10, 2012). "Kyoto Prize Is Awarded to 3 Scholars". The Chronicle of Higher Education Blogs: The Ticker. Retrieved October 4, 2016.
- ^ "Laureates—Breakthrough Prize". Breakthrough Prize. Retrieved December 5, 2016.
- ^ "The Nobel Prize in Physiology or Medicine 2016". The Nobel Foundation. October 3, 2016. Retrieved October 3, 2016.
- ^ a b "Yoshinori Ohsumi Biography". Institute of Innovative Research, Tokyo Institute of Technology. Retrieved October 10, 2016.
- ^ "Yoshinori Ohsumi: What is autophagy? A dynamic cellular recycling process". Molecular Frontiers Symposium at the Tokyo Institute of Technology, Japan. October 2017. Retrieved January 15, 2018.
- Wikidata Q57407776.
- Wikidata Q29614174.
- ^ "Yoshinori Ohsumi – Nobel Lecture: Autophagy – an Intracellular Recycling System". Nobel Prize. December 7, 2016. Retrieved January 15, 2018.
- ^ Kolata, Gina; Chan, Sewell (October 3, 2016). "Yoshinori Ohsumi of Japan Wins Nobel Prize for Study of 'Self-Eating' Cells". The New York Times. Retrieved October 10, 2016.
- ^ Wanklyn, Alastair (October 3, 2016). "Japanese microbiologist Yoshinori Ohsumi wins Nobel in medicine for autophagy research". The Japan Times. Retrieved October 8, 2016.
- ^ "大隅萬里子教授の共同研究がノーベル医学・生理学賞として選定されました" [A joint research of Professor Mariko Ohsumi won Nobel Prize in Physiology or Medicine]. Teikyo University of Science. October 5, 2016.
- ^ "Google Scholar". Scholar.google.com.
- ^ "Yoshinori Ohsumi". Kyoto Prize. Retrieved October 3, 2016.
- ^ "Yoshinori Ohsumi wins Nobel prize in medicine for work on autophagy". The Guardian. Retrieved October 3, 2016.
- ^ "Breakthrough Prize – Life Sciences : Breakthrough Prize Laureates – Yoshinori Ohsumi". Breakthroughprize.org. Retrieved October 15, 2018.
- ^ a b "Nobel Prize Laureate Yoshinori Ohsumi's Work". Jstor Daily. October 3, 2016.
External links
- Yoshinori Ohsumi on Nobelprize.org inclkuding the Nobel Lecture December 7, 2016 Molecular Mechanisms of Autophagy in Yeast