ZNF238
ZBTB18 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process |
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Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 1: 244.05 – 244.06 Mb | Chr 1: 177.27 – 177.28 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Zinc finger protein 238 (also known as RP58 or ZBTB18) is a zinc finger containing transcription factor that in humans is encoded by the ZNF238 gene.[5][6]
Function
ZNF238 is a gene that plays a major role in the "promotion of ordered and correctly timed
In tumors such as medulloblastomas, the loss of ZNF238 can disorganize the tumor's cellular divisional processes, resulting in a cellularly diverse neoplasm. This new diversity has been observed to increase the invasiveness of the tumor, yielding proliferation into more areas of the brain than before the loss of ZNF238.
C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly.[8]
Interactions
ZNF238 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000179456 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063659 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 37032889.
- S2CID 46704829.
- ^ PMID 22095278.
- ^ "Entrez Gene: ZNF238 zinc finger protein 238".
- PMID 11350943.
Further reading
- Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature (PDF). 377 (6547 Suppl): 3–174. PMID 7566098.
- Becker KG, Nagle JW, Canning RD, Biddison WE, Ozato K, Drew PD (April 1995). "Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain". Human Molecular Genetics. 4 (4): 685–91. PMID 7633419.
- Aoki K, Meng G, Suzuki K, Takashi T, Kameoka Y, Nakahara K, Ishida R, Kasai M (October 1998). "RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression". The Journal of Biological Chemistry. 273 (41): 26698–704. PMID 9756912.
- Ahmad KF, Engel CK, Privé GG (October 1998). "Crystal structure of the BTB domain from PLZF". Proceedings of the National Academy of Sciences of the United States of America. 95 (21): 12123–8. PMID 9770450.
- Meng G, Inazawa J, Ishida R, Tokura K, Nakahara K, Aoki K, Kasai M (January 2000). "Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin". Gene. 242 (1–2): 59–64. PMID 10721697.
- Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T (May 2001). "Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription". The EMBO Journal. 20 (10): 2536–44. PMID 11350943.
External links
- ZNF238+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.