ZNF238

Source: Wikipedia, the free encyclopedia.
ZBTB18
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_001278196
NM_006352
NM_205768

RefSeq (protein)

NP_001265125
NP_006343
NP_991331

Location (UCSC)Chr 1: 244.05 – 244.06 MbChr 1: 177.27 – 177.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 238 (also known as RP58 or ZBTB18) is a zinc finger containing transcription factor that in humans is encoded by the ZNF238 gene.[5][6]

Function

ZNF238 is a gene that plays a major role in the "promotion of ordered and correctly timed

Ngn2 and Neurod1 (in progenitor cells, and an increase thereof in mutant neurons), with the result of less progenitor cells and an increase in neuronal differentiation and glial cell growth.[7] ZNF238 also regulates repressed genes that, if left unchecked, can lead to glioma progression. Furthermore, an absence of ZNF238 results in upregulation of the epithelial-mesenchymal transition
process.

In tumors such as medulloblastomas, the loss of ZNF238 can disorganize the tumor's cellular divisional processes, resulting in a cellularly diverse neoplasm. This new diversity has been observed to increase the invasiveness of the tumor, yielding proliferation into more areas of the brain than before the loss of ZNF238.

C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly.[8]

Interactions

ZNF238 has been shown to

DNMT3A.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179456 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063659 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. S2CID 37032889
    .
  6. .
  7. ^ .
  8. ^ "Entrez Gene: ZNF238 zinc finger protein 238".
  9. PMID 11350943
    .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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