Zinc finger and BTB domain-containing protein 16
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| Location (UCSC) | Chr 11: 114.06 – 114.26 Mb | Chr 9: 48.57 – 48.75 Mb | |||||||
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Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.
Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a
gamma-delta T cells.[8] Alternate transcriptional splice variants have been characterized in human.[9][10]
Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to
interact
with:
- Angiotensin II receptor type 1,[11]
- BCL6,[12]
- BMI1,[13]
- FHL2,[16]
- GATA1,[17]
- GATA2,[18]
- HDAC1,[19][20][21]
- HDAC4,[19][22]
- HDAC5,[19][22]
- HDAC6,[19]
- Heparin-binding EGF-like growth factor,[23][24]
- Nuclear receptor co-repressor 2,[21][25][26]
- Promyelocytic leukemia protein[27]
- RUNX1T1,[28][29]
- Retinoic acid receptor alpha,[30]
- SIN3A,[14][20][21]
- SIN3B,[20] and
- ZBTB32.[31]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109906 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066687 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8384553.
- PMID 18660811.
- PMID 18703361.
- PMID 19617548.
- PMID 10500192.
- ^ "ZBTB16 zinc finger and BTB domain containing 16". Entrez. 4 October 2009. Retrieved 10 October 2009.
- PMID 14657020.
- S2CID 23619694.
- PMID 12408802.
- ^ PMID 11719366.
- PMID 12460926.
- PMID 12145280.
- PMID 12242665.
- PMID 11964310.
- ^ S2CID 26092755.
- ^ S2CID 655636.
- ^ PMID 9765306.
- ^ S2CID 19024903.
- PMID 14597771.
- PMID 15219838.
- PMID 14982881.
- PMID 9256429.
- PMID 9294197.
- PMID 10688654.
- PMID 11090081.
- PMID 14521715.
- PMID 10572087.
Further reading
- Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A (1993). "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". The EMBO Journal. 12 (3): 1161–7. PMID 8384553.
- Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derré J, Berger R, Waxman S, Chen Z (1993). "Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia". The Journal of Clinical Investigation. 91 (5): 2260–7. PMID 8387545.
- Reid A, Gould A, Brand N, Cook M, Strutt P, Li J, Licht J, Waxman S, et al. (1995). "Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors". Blood. 86 (12): 4544–52. PMID 8541544.
- Dong S, Zhu J, Reid A, Strutt P, Guidez F, Zhong HJ, Wang ZY, Licht J, et al. (1996). "Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein". Proceedings of the National Academy of Sciences of the United States of America. 93 (8): 3624–9. PMID 8622986.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548.
- Hong SH, David G, Wong CW, Dejean A, Privalsky ML (1997). "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9028–33. PMID 9256429.
- Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, et al. (1997). "Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10255–60. PMID 9294197.
- Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–4. S2CID 4383951.
- Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood. 91 (8): 2634–42. PMID 9531570.
- David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. S2CID 655636.
- Ahmad KF, Engel CK, Privé GG (1998). "Crystal structure of the BTB domain from PLZF". Proceedings of the National Academy of Sciences of the United States of America. 95 (21): 12123–8. PMID 9770450.
- van Schothorst EM, Prins DE, Baysal BE, Beekman M, Licht JD, Waxman S, Zelent A, Cornelisse CJ, et al. (1999). "Genomic structure of the human PLZF gene". Gene. 236 (1): 21–4. PMID 10433962.
- Ball HJ, Melnick A, Shaknovich R, Kohanski RA, Licht JD (1999). "The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase". Nucleic Acids Research. 27 (20): 4106–13. PMID 10497277.
- Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, et al. (1999). "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11422–7. PMID 10500192.
- Li X, Peng H, Schultz DC, Lopez-Guisa JM, Rauscher FJ, Marmorstein R (1999). "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein". Cancer Research. 59 (20): 5275–82. PMID 10537309.
- Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, et al. (1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. PMID 10572087.
- Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (2000). "The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein". Molecular and Cellular Biology. 20 (6): 2075–86. PMID 10688654.
- Hyman J, Chen H, Di Fiore PP, De Camilli P, Brunger AT (2000). "Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)". The Journal of Cell Biology. 149 (3): 537–46. PMID 10791968.
- Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47. PMID 11090081.
- Beez S, Demmer P, Puccetti E (2012). "Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides". PLOS ONE. 7 (11): e48636. PMID 23152790.
- He LZ, Bhaumik M, Tribioli C, Rego EM, Ivins S, Zelent A, Pandolfi PP (2000). "Two critical hits for promyelocytic leukemia". Molecular Cell. 6 (5): 1131–41. PMID 11106752.
External links
- ZBTB16+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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