Överkalix study
The Överkalix study (
The study started with 320
The study found that a severe increase/decrease in food supply in male ancestors shortly before puberty was linked to a change in death rates from cardiovascular disease (CVD) and diabetes rates in their descendants. In particular children of a father who suffered a deficit of food had lower rates of deaths from CVD, and a paternal grandfather who suffered a similar deficit saw a reduction in deaths from diabetes in their grandchildren. Conversely a surplus in food supply for a paternal grandfather saw a 4-fold increase in the number of diabetes-related deaths in their grandchildren.
These effects were observed correlating with food surplus/deficit during the slow growth period (SGP). The SGP is the time before the start of puberty, when environmental factors have a larger impact on the body. The ancestors' SGP in this study, was set between the ages of 9-12 for boys and 8–10 years for girls. This occurred in the SGP of both grandparents, or during the gestation period/infant life of the grandmothers, but not during either grandparent's puberty.
The study notes a number of potential issues, including small sample sizes, borderline statistical significance, progeny size effects, puberty estimation, regional food access and environmental effects.[1] A 2018 study attempted to replicate these findings using a much larger sample of over 11,500 grandchildren using data from the Uppsala Multigeneration Study. It failed to replicate the association with either cardiovascular or diabetes mortality, but did report an increased all-cause mortality correlated to SGP food intake, mostly due to cancer.[2]
Sex-specific effects can be due to parental imprinting, a process that results in allele-specific differences in transcription,
The estimation of percentage of human genes subject to parental imprinting is approximately one to two percent, currently parental imprinting has been identified in fewer than 100 distinct named genes.[3]
See also
- Dutch famine of 1944–45