Acediasulfone

Acediasulfone
Clinical data
ATC code	none;
Identifiers
	IUPAC name 2-([4-(4-aminophenyl)sulfonylphenyl]amino)acetic acid;
JSmol)	Interactive image;
	SMILES C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)NCC(=O)O;
	InChI InChI=1S/C14H14N2O4S/c15-10-1-5-12(6-2-10)21(19,20)13-7-3-11(4-8-13)16-9-14(17)18/h1-8,16H,9,15H2,(H,17,18) ; Key:FKKUMFTYSTZUJG-UHFFFAOYSA-N ;
	(verify)

Acediasulfone (

antimalarial activity. It is a long-acting prodrug of dapsone, which is used for treating leprosy

.

Synthesis

Dapsone is somewhat inconvenient to administer to patients because of its rather low water solubility.

In the search for more easily administered drugs, dapsone (1) was reacted with bromoacetic acid to give acediasulfone (2) which can be administered as a water-soluble salt.

References

PMID 18907772
.

drug article is a stub. You can help Wikipedia by expanding it.
v
t
e

[1] PMID 18907772
.

[1]