Angiopoietin 1
Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.[5] During pregnancy, angiopoietins act complementary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels. Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR).
A knockout model of ANGPT1 was introduced in mice embryos. Results showed that embryos began to appear abnormal by day 11 and were dead by day 12.5 of pregnancy. The embryos showed prominent defects in endocardial and myocardial development as well as a less complex vascular network.
Interactions
Angiopoietin 1 has been shown to
Placental Malaria
Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with Plasmodium (the causative agent of malaria).[12] In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta.[13] This suggests that angiopoietin levels could be clinically significant biomarkers to identify mothers infected with PM.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000154188 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022309 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ANGPT1 angiopoietin 1".
- S2CID 15926708.
- ^ Kappou D, Sifakis S, Konstantinidou A, et al. Role of angiopoietin/Tie system in pregnancy.Experimental and Therapeutic Medicine. 2015; 9(4): 1091-1096.
- PMID 12427764.
- S2CID 17197564.
- PMID 9723709.
- PMID 9204896.
- PMID 26090803.
- PMID 20208992.
Further reading
- Nakajima D, Okazaki N, Yamakawa H (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.
- Metheny-Barlow LJ, Li LY (2004). "The enigmatic role of angiopoietin-1 in tumor angiogenesis". Cell Res. 13 (5): 309–17. PMID 14672554.
- Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling". Curr. Mol. Med. 6 (8): 831–41. PMID 17168735.
- Nomura N, Miyajima N, Sazuka T (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. PMID 7584026.
- Nomura N, Miyajima N, Sazuka T (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. PMID 7584028.
- Rüegg C, Pytela R (1995). "Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein". Gene. 160 (2): 257–62. PMID 7642106.
- Davis S, Aldrich TH, Jones PF (1997). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 (7): 1161–9. S2CID 17197564.
- Suri C, Jones PF, Patan S (1997). "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell. 87 (7): 1171–80. S2CID 15926708.
- Maisonpierre PC, Suri C, Jones PF (1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. PMID 9204896.
- Ristimäki A, Narko K, Enholm B (1998). "Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C". J. Biol. Chem. 273 (14): 8413–8. PMID 9525952.
- Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics. 48 (3): 389–91. PMID 9545648.
- Witzenbichler B, Maisonpierre PC, Jones P (1998). "Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2". J. Biol. Chem. 273 (29): 18514–21. PMID 9660821.
- Sato A, Iwama A, Takakura N (1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. 10 (8): 1217–27. PMID 9723709.
- Valenzuela DM, Griffiths JA, Rojas J (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. PMID 10051567.
- Grosios K, Leek JP, Markham AF (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 118–20. S2CID 40232421.
- Procopio WN, Pelavin PI, Lee WM, Yielding NM (1999). "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity". J. Biol. Chem. 274 (42): 30196–201. PMID 10514510.
- Huang YQ, Li JJ, Karpatkin S (2000). "Identification of a family of alternatively spliced mRNA species of angiopoietin-1". Blood. 95 (6): 1993–9. S2CID 34946654.
- Kim I, Kim JH, Ryu YS (2000). "Characterization and expression of a novel alternatively spliced human angiopoietin-2". J. Biol. Chem. 275 (24): 18550–6. PMID 10766762.
- Dunk C, Shams M, Nijjar S (2000). "Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development". Am. J. Pathol. 156 (6): 2185–99. PMID 10854239.
- Krikun G, Schatz F, Finlay T (2000). "Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation". Biochem. Biophys. Res. Commun. 275 (1): 159–63. PMID 10944458.
External links
- Human ANGPT1 genome location and ANGPT1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.