B3GAT1

Source: Wikipedia, the free encyclopedia.
B3GAT1
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_018644
NM_054025
NM_001367973

NM_029792
NM_001310766

RefSeq (protein)

NP_061114
NP_473366
NP_001354902

NP_001297695
NP_084068

Location (UCSC)Chr 11: 134.38 – 134.41 MbChr 9: 26.65 – 26.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

3-beta-glucuronosyltransferase 1 (B3GAT1) is an

adhesion molecules of the nervous system.[6]

Function

The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized.[5]

Immunohistochemistry

In anatomical pathology, CD57 (immunostaining) is similar to CD56 for use in differentiating

lymphocytes, CD57 positive cells are typically either T cells or NK cells, and are most commonly found within the germinal centres of lymph nodes, tonsils, and the spleen.[8]

There is an increase in the number of circulating CD57 positive cells in the blood of patients who have recently undergone organ or tissue transplants, especially of the bone marrow, and in patients with HIV. Increased CD57+ counts have also been reported in rheumatoid arthritis and Felty's syndrome, among other conditions.[8] High levels of CD57 expression amongst circulating CD8+ T cells is associated with other markers of immune ageing (immunosenescence) and may be associated with increased cancer risk in renal transplant recipients.[9]

NSE.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109956 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045994 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)".
  6. PMID 10783264
    .
  7. .
  8. ^ .
  9. .

Further reading

External links

This page is based on the copyrighted Wikipedia article: B3GAT1. Articles is available under the CC BY-SA 3.0 license; additional terms may apply.Privacy Policy