Balovaptan
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Other names | RG7314 |
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Balovaptan (
Clinical studies
Post-traumatic stress disorder
It was in a phase III clinical trial for adults and a phase II clinical trial for children for this indication.[2]
Autism
In January 2018, Roche announced that the US Food and Drug Administration (FDA) had granted breakthrough therapy designation for balovaptan in people with autism spectrum disorder (ASD).[3] The FDA granted this based on the results of the adult phase II clinical trial called VANILLA (Vasopressin ANtagonist to Improve sociaL communication in Autism) study.[4] The phase III adult study (March 2020) is called V1aduct and the phase II child study is called Av1ation.[citation needed]
The phase III study concluded that balovaptan did not improve social communication in autistic adults.[5]
It was also in phase II studies for the treatment of stroke. However, it has since been discontinued for both of those indications, and is only being developed for post-traumatic stress disorder, with plans to submit regulatory filings in 2025 or later.[6]
References
- ^ "Roche - Pipeline". 2023. Retrieved 5 April 2023.
- ^ Clinical trial number NCT01793441 for "Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders" at ClinicalTrials.gov
- ^ "FDA grants Breakthrough Therapy Designation for Roche's balovaptan in autism spectrum disorder" (Press release). 29 January 2018. Retrieved 6 February 2018.
- PMID 31043521.
- PMID 35151410.
- ^ "Balovaptan". Adis Insight. Springer Nature Switzerland AG. Retrieved 5 April 2023.