C14orf102

NRDE2
Identifiers
Gene ontology
Molecular function	molecular function;
Cellular component	catalytic step 2 spliceosome; cellular component;
Biological process	heterochromatin assembly by small RNA; RNA interference; biological process;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000119720


ENSMUSG00000021179

UniProt


Q9H7Z3


Q80XC6

RefSeq (mRNA)


NM_017970 NM_199043


NM_001290303 NM_183155 NM_001377383

RefSeq (protein)


NP_060440


NP_001277232 NP_898978 NP_001364312

Location (UCSC)

Chr 14: 90.27 – 90.33 Mb

Chr 12: 100.09 – 100.13 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Chromosome 14

protein binding function and localization in the cytoplasm.^[7]

Expression

According to EST profiles, C14orf102 is most highly expressed in the
brain tissue
. The general expression of the gene is high, being 1.8 times that of average gene expression.

Protein

The protein contains five HAT (
codons (PTCs) – sequences that encode truncated amino acid sequences.^[10]

Interaction

C14orf102 interacts with
nuclear export and surveillance of mRNA.^[6] Surveillance by the RNPS1 protein initiates NMD after identification of exported, PTC-containing mRNA. Because UPF0614
is expected to be located in the cytoplasm and function in protein binding, this interaction supports the potential role of UPF0614 in the NMD pathway.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119720 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021179 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ C14orf102 Gene - GeneCards | CN102 Protein | CN102 Antibody

^ ^a ^b AceView: Gene:C14orf102, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView

^ C14orf102 (human)

^ EST Profile - Hs.528131

^ UPF0614 protein C14orf102 - Homo sapiens (Human)

^ "Archived copy" (PDF). Archived from the original (PDF) on 2010-06-24. Retrieved 2011-05-10.{{cite web}}: CS1 maint: archived copy as title (link)

Retrieved from "https://en.wikipedia.org/w/index.php?title=C14orf102&oldid=1139303221"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119720 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021179 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] C14orf102 Gene - GeneCards | CN102 Protein | CN102 Antibody

[autogenerated1-6] AceView: Gene:C14orf102, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView

[7] C14orf102 (human)

[8] EST Profile - Hs.528131

[9] UPF0614 protein C14orf102 - Homo sapiens (Human)

[10] "Archived copy" (PDF). Archived from the original (PDF) on 2010-06-24. Retrieved 2011-05-10.{{cite web}}: CS1 maint: archived copy as title (link)

[3]

[4]

[7]

[10]

[6]